Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives(Ⅲ):Mono- and bis-Schiff-bases

查看全文 作　　者：Guo Qiang [1]Hu;Xiao Kui [1]Wu;Guo Qiang [1]Wang;Nan Nan [1]Duan;Xiao Yi [1]Wen;Tie Yao [1]Cao;Yin [1]Jun;Wang [1]Wei;Song Qiang [1]Xie;Wen Long [2]Huang

机构地区：[1]Institute of Chemistry&Biology,Henan University,Kaifeng 475001,China;[2]China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Chemical Letters》索引2012年第23卷第5期,共3页

基　　金：supported by the National Natural Science Foundation of China(Nos20872028 and 21072045) 摘　　要：To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized,and their in vitro antitumor activity against CHO,HL60,L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported. 关键词：体外抗肿瘤活性抗菌活性氟喹诺酮喹诺酮衍生物合成 Schiff碱金黄色葡萄球菌 CHO细胞

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Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives(Ⅲ):Mono- and bis-Schiff-bases

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