Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells

查看全文 作　　者：Xinjian [1,2]Liu;Fang [1]Li;Elizabeth A [3]Stubblefield;Barbara [4]Blanchard;Toni L [3]Richards;Gaynor A [3]Larson;Yujun [5]He;Qian [2]Huang;Aik-Choon [4]Tan;Dabing [6]Zhang;Timothy A [3,4,7]Benke;John R [4,7]Sladek;Nancy R [3]Zahniser;Chuan-Yuan [1,3,8,9]Li

机构地区：[1]Departments of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA,;[2]Shanghai First People's Hospital School of Medicine, Shanghai Jiaotong University, Shanghai 201620, China;[3]Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA,;[4]Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA;[5]Third Military Medical University, Chongqing 400038, China;[6]School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China;[7]Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA;[8]Charles Gates Center for Stem Cell and Regenerative Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA;[9]Current address: Department of Dermatology, Box 3135, Duke UniversityMedical Center, Durham, NC 27710, USA

出　　处：《Cell Research》索引2012年第22卷第2期,共12页

摘　　要：外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 关键词：多巴胺能神经元神经元样细胞成纤维细胞重新编程人类多巴胺神经元替代治疗转录因子

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Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells

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