Current understanding of ovarian aging

查看全文 作　　者：LI [1]Qian;GENG [1]XiaoDan;ZHENG [1]Wei;TANG [1]Jie;XU [1]Bo;SHI [1]QingHua

机构地区：[1]Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences,University of Science and Technology of China,Hefei 230027,China

出　　处：《Science China(Life Sciences)》索引2012年第55卷第8期,共11页

基　　金：supported by the National Basic Research Program of China (Grant Nos. 2012CB944402,2011CB944501 and 2007CB947401);Program of Knowledge Innovation of Chinese Academy of Sciences (GrantNo. KSCX2-EW-R-07) 摘　　要：The reproductive system of human female exhibits a much faster rate of aging than other body systems.Ovarian aging is thought to be dominated by a gradual decreasing numbers of follicles,coinciding with diminished quality of oocytes.Menopause is the final step in the process of ovarian aging.This review focuses on the mechanisms underlying the ovarian aging involving a poor complement of follicles at birth and a high rate of attrition each month,as well as the alternated endocrine factors.We also discuss the possible causative factors that contribute to ovarian aging,e.g.,genetic factors,accumulation of irreparable damage of microenvironment,pathological effect and other factors.The appropriate and reliable methods to assess ovarian aging,such as quantification of follicles,endocrine measurement and genetic testing have also been discussed.Increased knowledge of the ovarian aging mechanisms may improve the prevention of premature ovarian failure. 关键词：衰老机制卵巢卵母细胞质量生殖系统遗传因素致病因素内分泌老化

相关文献

参考文献（165）
引证文献（15）
耦合文献（25）

参考文献(165)

引证文献(15)

耦合文献(25)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Current understanding of ovarian aging

参考文献(165)

引证文献(15)

耦合文献(25)

用户提示