Brain-derived neurotrophic factor inhibits glucose intolerance after cerebral ischemia

查看全文 作　　者：Xiaoliang [1]Shu;Yongsheng [2]Zhang;Han [1]Xu;Kai [1]Kang;Donglian [3]Cai

机构地区：[1]Department of Nutrition,Affiliated Dongfang Hospital of Tongji University;[2]Department of Nutrition,First Affiliated Hospital of Guangxi Medical University;[3]Department of Nutrition,Affiliated Changhai Hospital of the Second Military Medical University of Chinese PLA

出　　处：《Neural Regeneration Research》索引2013年第8卷第25期,共9页

基　　金：supported by the Talent Foundation of the Affiliated Hospital of Guangxi Medical College in China,No.08026;Youth Researcher Foundation of Guangxi Medical College in China,No.08012;Scientific Research Foundation from Science and Technology Bureau of Shanghai City,No.074119048 摘　　要：Brain-derived neurotrophic factor is associated with the insulin signaling pathway and glucose metabolism.We hypothesized that expression of brain-derived neurotrophic factor and its receptor may be involved in glucose intolerance following ischemic stress.To verify this hypothesis,this study aimed to observe the changes in brain-derived neurotrophic factor and tyrosine kinase B receptor expression in glucose metabolism-associated regions following cerebral ischemic stress in mice.At day 1 after middle cerebral artery occlusion,the expression levels of brain-derived neurotrophic factor were significantly decreased in the ischemic cortex,hypothalamus,liver,skeleta muscle,and pancreas.The expression levels of tyrosine kinase B receptor were decreased in the hypothalamus and liver,and increased in the skeletal muscle and pancreas,but remained unchanged in the cortex.Intrahypothalamic administration of brain-derived neurotrophic factor(40ng)suppressed the decrease in insulin receptor and tyrosine-phosphorylated insulin receptor expression in the liver and skeletal muscle,and inhibited the overexpression of gluconeogenesis-associated phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in the liver of cerebral ischemic mice.However,serum insulin levels remained unchanged.Our experimental findings indicate that brain-derived neurotrophic factor can promote glucose metabolism,reduce gluconeogenesis,and decrease blood glucose levels after cerebral ischemic stress.The low expression of brain-derived neurotrophic factor following cerebral ischemia may be involved in the development of glucose intolerance. 关键词：脑源性神经营养因子脑缺血葡萄糖胰岛素受体酪氨酸激酶血糖水平信号转导通路酪氨酸磷酸化

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Brain-derived neurotrophic factor inhibits glucose intolerance after cerebral ischemia

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