Synthesis, Biological Activity Evaluation and Molecular Modeling Study on the New Isoconessimine Derivatives as Acetylcholinesterase Inhibitors

查看全文 作　　者：Guofei [1]Jin;Zhongduo [1]Yang;Weiwei [2]Xue;Jie [1]Sheng;Yin [3]Shi;Xiaojun [2]Yao

机构地区：[1]School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, Gansu 730050, China;[2]Department of Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China;[3]Key Lab of New Animal Drug Project, Gansu Province; Key Lab of Veterinary Pharmaceutical Development, Ministry of Agriculture; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu 730050, China

出　　处：《Chinese Journal of Chemistry》索引2013年第31卷第9期,共6页

基　　金：The authors are grateful to the National Natural Science Foundation of China,the Excellent Young Teachers Program of Lanzhou University of Technology,Zhejiang Provincial Natural Science Foundation of China,the open fund of the Key Laboratory of the New Animal Drug Project of Gansu Province and the Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture 摘　　要：新 isoconessimine 衍生物从 conessine (1 ) 被综合并且作为 acetylcholinesterase (疼痛) 评估了禁止者。衍生物经由二反应步, N-demethylation 和亲核的替换被准备。所有比 conessine (1 ) 综合衍生物展出了更潜在的 anti-acetylcholinesterase 活动(IC50=16 ???? 作吗?? 关键词：乙酰胆碱酯酶抑制剂衍生物生物活性评价合成分子模拟 IC50 活性位点化合物

相关文献

参考文献（22）
引证文献（1）
耦合文献（0）

参考文献(22)

引证文献(1)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Synthesis, Biological Activity Evaluation and Molecular Modeling Study on the New Isoconessimine Derivatives as Acetylcholinesterase Inhibitors

参考文献(22)

引证文献(1)

用户提示