A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5

查看全文 作　　者：WU [1]LianQiu;ZHANG [1]XueMei;CHE [1]YanChun;ZHANG [1]Ying;TANG [1]SongQing;LIAO [1]Yun;NA [1]RuiXiong;XIONG [2]XiangLin;LIU [1]LongDing;LI [1]QiHan

机构地区：[1]Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases,Institute of Medical Biology,Chinese Academy of Medical Sciences & Peking Union Medical College;[2]Kunming Medical University

出　　处：《Science China(Life Sciences)》索引2013年第56卷第12期,共10页

基　　金：supported by the National Basic Research Program of China(2012CB518901);the National Natural Science Foundation of China(31100127) 摘　　要：Studies of herpes simplex virus type 1(HSV-1)infection have shown that many known and unknown cellular molecules involved in viral proliferation are up-regulated following HSV-1 infection.In this study,using two-dimensional polyacrylamide gel electrophoresis,we found that the expression of the HSV-1 infection response repressive protein(HIRRP,GI 16552881)was up-regulated in human L02 cells infected with HSV-1.HIRRP,an unknown protein,was initially localized in the cytoplasm and then translocated into the nucleus of HSV-1-infected cells.Further analysis showed that HIRRP represses HSV-1proliferation by inhibiting transcription of the viral genome by interacting with the cellular transcription factor,ATF5,via its N-terminal domain.ATF5 represses the transcription of many host genes but can also act as an activator of genes containing a specific motif.We found that ATF5 promotes the proliferation of HSV-1 via a potential mechanism by which ATF5 enhances the transcription of viral genes during the course of an HSV-1 infection;HIRRP then induces feedback repression of this transcription by interacting with ATF5. 关键词：HSV-1 感染细胞细胞反应相互作用抑制蛋白病毒复制聚丙烯酰胺凝胶电泳病毒基因组

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A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5

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引证文献(3)

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