Toxic Effects of Atrazine on Reproductive System of Male Rats

查看全文 作　　者：SONG [1]Yang;JIA Zhen [1]Chao;CHEN Jin [1]Yao;HU Jun [1]Xiang;ZHANG Li [1]Shi

机构地区：[1]Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University

出　　处：《Biomedical and Environmental Sciences》索引2014年第27卷第4期,共8页

基　　金：supported by National Natural Science Foundation of China(81030053);National High-technology Research and Development Program(‘863’program)of China(2010AA023001) 摘　　要：Objective This study was designed to evaluate the toxic effects of Atrazine(ATZ) on the reproductive system of male rats. Methods Male Sprague-Dawley rats were exposed to ATZ by gavage at dosages of 0, 38.5, 77, and 154 mg/kg bw/day for 30 d. The toxic effects of ATZ to rats were assessed through histopathologcal observation, spermatozoa quality evaluation, testicular marker enzyme indicators, antioxidant capacity and reproductive hormone levels. Results Significant adverse effects on reproductive system were observed in rats exposed to ATZ at different dosages compared with 0 mg/kg group, including an irregular and disordered arrangement of the seminiferous epithelium in 154 mg/kg group; a decreased spermatozoa number and an increased spermatozoa abnormality rate in 77 and 154 mg/kg groups; decreased levels of acid phosphatase(ACP), alkaline phosphatase(AKP), lactic dehydrogenase(LDH), and succinate dehydrogenase(SDH) with the increasing of ATZ concentration; a decreased level of total antioxidant capacity(TAC) in a dose-dependent manner, and a decreased reduced glutathione(GSH) level and an increased malondialdehyde(MDA) content in 154 mg/kg group; and decreased serum levels of testosterone(T) and inhibin-B(INH-B) and an increased serum level of follicle stimulating hormone(FSH) in 77 and 154 mg/kg groups, and an increased serum level of luteinizing hormone(LH) in 154 mg/kg group. Conclusion These results suggested that relatively high doses of ATZ could exert reproductive toxicity of male rats. 关键词：雄性大鼠生殖系统阿特拉津 SPRAGUE-DAWLEY 毒性效应总抗氧化能力还原型谷胱甘肽激素水平

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Toxic Effects of Atrazine on Reproductive System of Male Rats

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