维普中文期刊产品整合服务

Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague

查看全文 作　　者：Zongmin [1]Du;Huiying [1]Yang;Yafang [1]Tan;Guang [1]Tian;Qingwen [2]Zhang;Yujun [1]Cui;Yanfeng [1]Yan;Xiaohong [1]Wu;Zuyun [3]Chen;Shiyang [1]Cao;Yujing [1]Bi;Yanping [1]Han;Xiaoyi [1]Wang;Yajun [1]Song;Ruifu [1]Yan 高影响力作者 机构地区：[1]State Key Laboratory of Pathogen and Biosecurity,Institute of Microbiology and Epidemiology;[2]Qinghai Institute for Endemic Disease Prevention and Control of Qinghai Province;[3]BGI-Shenzhen高影响力机构 出　　处：《Journal of Genetics and Genomics》索引2014年第41卷第7期,共18页高影响力期刊 基　　金：supported by the National Basic Research Program of China(Nos.2012CB518704 and 2013CB910804);the National Natural Science Foundation of China(No.31170122);the Basic Research Programs of Science and Technology Department Foundation of QingHai Province(No.2013-Z-748) 摘　　要：Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. 关 键 词：信号转导通路 鼠疫耶尔森氏菌 动力学反应 受体 细菌感染 主机 瘟疫 对抗
相关文献

参考文献(81)

引证文献(2)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费