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Morphological MRI and T2 mapping of cartilage repair tissue after mosaicplasty with tissue-engineered cartilage in a pig model

查看全文 作　　者：Qichun [1]Chen;Qiang [2]Zuo;Qianqian [3]Hu;Yang [3]Feng;Weiding [2]Cui;Weimin [2]Fan;Yuefen [3]Zou 高影响力作者 机构地区：[1]Department of Radiology,the Second Hospital of Anhui Medical University;[2]Department of Orthopedics,the First Affiliated Hospital of Nanjing Medical University;[3]Department of Radiology,the First Affiliated Hospital of Nanjing Medical University高影响力机构 出　　处：《The Journal of Biomedical Research》索引2014年第28卷第4期,共11页高影响力期刊 基　　金：supported by the National Natural Science Foundation ofChina(No.81000800) 摘　　要：The aim of this study was to evaluate the efficacy of mosaicplasty with tissue-engineered cartilage for the treatment of osteochondral defects in a pig model with advanced MR technique.Eight adolescent miniature pigs were used.The right knee underwent mosaicplasty with tissue-engineered cartilage for treatment of focal osteochondral defects,while the left knee was repaired via single mosaicplasty as controls.At 6,12,18 and 26 weeks after surgery,repair tissue was evaluated by magnetic resonance imaging(MSI)with the cartilage repair tissue(MOCART)scoring system and T2mapping.Then,the results of MRI for 26 weeks were compared with findings of macroscopic and histologic studies.The MOCART scores showed that the repaired tissue of the tissue-engineered cartilage group was statistically better than mat of controls(P<0.001).A significant correlation was found between macroscopic and MOCART scores(P<0.001).Comparable mean T2 values were found between adjacent cartilage and repair tissue in the experimental group(P>0.05).For zonal T2 value evaluation,there were no significant zonal T2 differences for repair tissue in controls(P>0.05).For the experimental group,zonal T2 variation was found in repair tissue(P<0.05).MRI,macroscopy and histology showed better repair results and bony incorporation in mosaicplasty with the tissue-engineered cartilage group than those of the single mosaicplasty group.Mosaicplasty with the tissue-engineered cartilage is a promising approach to repair osteochodndral defects.Morphological MRI and T2 mapping provide a non-invasive method for monitoring the maturation and integration of cartilage repair tissue in vivo. 关 键 词：组织工程化 骨修复 MRI 小型猪 软骨 映射 形态 模型
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