Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice

查看全文 作　　者：Jizheng [1]Chen;Yang [2]Zhao;Chao [2]Zhang;Hairong [2]Chen;Jin [2]Feng;Xiumei [3]Chi;Yu [3]Pan;Jun [4]Du;Min [1]Guo;Huang [1]Cao;Honghe [1]Chen;Zilong [1]Wang;Rongjuan [1]Pei;Qian [5]Wang;Lei [2]Pan;Junqi [3]Niu;Xinwen [1]Chen;Hong [1,2]Tang

机构地区：[1]State Key Laboratory of Virology and the Center for Viral Pathology, Wuhan Institute of Virology, Chinese Academy of Sciences,Wuhan, Hubei 430071, China;[2]Key Laboratory of Infection and lmmunity, Institute of Biophysics, Chinese Academy of Sciences,Beijing 100101, China;[3]Department of Hepatology, The First Hospital of Jilin University, Changehun, Jilin 130021, China;[4]TheInstitute of Bioteehnology, Shanxi University, Taiyuan, Shanxi 030006, China;[5]Key Laboratory of Human Functional Genomics ofJiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 210093, China

出　　处：《Cell Research》索引2014年第24卷第9期,共17页

基　　金：Acknowledgments We are grateful to Drs T Wakita (National Institute of Infec- tious Diseases, Japan) for pJFH-1 clone, F Chisari (The Scripps Research Institute) for Huh7.5.1 cell line, L Su (University of North Carolina) for cDNA clones of human CD81 and Occludin, and C Rice (The Rockefeller University) for NS5A antibody. We thank Drs Y Tian and S Meng for making a series of transgenic mice; C-X Wei for the genotyping of transgenic mice. We thank Drs L Su, Y-X Fu (The University of Chicago), R Sun (University of California, Los Angeles) and P Hertzog (Monash University, Australia) for their critical reading and comments on the manuscript. This work was supported by grants from the National Basic Research Program of China (2009CB522506 and 2011CB946104 to HT, 2009CBl18903 to XC, and 2010CB530100 to LP), the National Natural Science Foundation of China (31200135 to XC and 31030031 to HT), Knowledge Innovation Program Projects of Chinese Academy of Science (2010-Biols-CAS-0201to HT, and KSCXI-YW-10 to XC and HT). 关键词：丙型肝炎病毒转基因小鼠病毒感染免疫能力人性化持续性慢性感染蛋白酶抑制剂

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Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice

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