Experimental infection of tree shrews(Tupaia belangeri) with Coxsackie virus A16

查看全文 作　　者：Jian-Ping [1]LI;Yun [1]LIAO;Ying [1]ZHANG;Jing-Jing [1]WANG;Li-Chun [1]WANG;Kai [1]FENG;Qi-Han [1]LI;Long-Ding [1]LIU

机构地区：[1]Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg

出　　处：《Zoological Research》索引2014年第35卷第6期,共7页

基　　金：supported by the National High-Tech R&D Program(2014ZX09102042);the National Natural Science Foundation of China(81373142);the Natural Science Foundation of Yunnan Province(2012ZA009) 摘　　要：Coxsackie virus A16(CA16) is commonly recognized as one of the main human pathogens of hand-foot-mouth disease(HFMD). The clinical manifestations of HFMD include vesicles of hand, foot and mouth in young children and severe inflammatory CNS lesions. In this study, experimentally CA16 infected tree shrews(Tupaia belangeri) were used to investigate CA16 pathogenesis. The results showed that both the body temperature and the percentages of blood neutrophilic granulocytes / monocytes of CA16 infected tree shrews increased at 4-7 days post infection. Dynamic distributions of CA16 in different tissues and stools were found at different infection stages. Moreover, the pathological changes in CNS and other organs were also observed. These findings indicate that tree shrews can be used as a viable animal model to study CA16 infection. 关键词：实验感染柯萨奇病毒树鼩嗜中性粒细胞中枢神经系统临床表现单核细胞动态分布

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Experimental infection of tree shrews(Tupaia belangeri) with Coxsackie virus A16

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耦合文献(96)

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