Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis

查看全文 作　　者：ZHANG [1]XinYuan;LIU [1,2]Wei;WU [3]ShanShan;JIN [4]JingLong;LI [4]WeiHong;Wang [1]NingLi

机构地区：[1]Beijing Institute of Ophthalmology,Tongren Eye Centre,Tongren Hospital,Capital Medical University;[2]University of Science and Technology Beijing;[3]Department of medical resources,Beijing Tongren Hospital,Capital Medical University;[4]Department of Epidemiology and Bio-statistics,Peking University Health Science Center

出　　处：《Science China(Life Sciences)》索引2015年第58卷第1期,共7页

基　　金：supported by grant from the National Natural Science Foundation of China(81170859);Bejing Municipal Education Commission Key Project(KZ201210025027);Beijing Science and Technology New Star Project(2004B28) 摘　　要：Many randomized clinical controlled trials have confirmed the efficacy and safety of calcium dobesilate in treating diabetic retinopathy(DR).This systematic review critically evaluated the evidence that links calcium dobesilate to DR.In this fixed-effects meta-analysis,a total of 221 pertinent English-language articles published between January 1975 and October 2013 were identified.Systematic searches of PUBMED,Springer Link and the Cochrane Clinical Trials Database were conducted using the keywords 'diabetic retinopathy' and 'calcium dobesilate'.The extracted information included the study design,inclusion and exclusion criteria,setting,sample size,participant mean age,treatment regime,mean change in best corrected visual acuity,laboratory parameters,capillary fragility,intraocular pressure and fundus manifestations based on the findings of fluorescent angiography.The summary statistics indicated that calcium dobesilate was significantly associated with improving retinal microaneurysms(RR: 0.62,95%CI: 0.42?0.90,P=0.01),retinalhemorrhages(RR: 0.39,95% CI: 0.17?0.88,P=0.02); exudates(RR: 0.31,95% CI: 0.12?0.81,P=0.02),reduction of whole blood viscosity(MD: ?0.57 CP,95% CI: ?0.75 to ?0.38,P<0.001),plasma viscosity(MD: ?0.36 CP,95% CI: ?0.63 to ?0.09,P=0.01) and blood cholesterol(MD: ?0.48 mg m L?1,95% CI: ?0.64?0.33,P<0.00001).Intraocular pressure was also significantly reduced(MD: ?5.59 mm Hg,95% CI: ?6.69 to ?4.50,P<0.00001).The results indicate that calcium dobesilate effectively treats DR at the systematic and local ocular levels. 关键词：糖尿病视网膜病变羟苯磺酸钙检索系统评价随机对照试验治疗方案试验数据库固定效应

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Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis

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