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Medium-Chain Triglyceride Activated Brown Adipose Tissue and Induced Reduction of Fat Mass in C57BL/6J Mice Fed High-fat Diet

查看全文 作　　者：ZHANG [1]Yong;XU [1]Qing;LIU Ying [1]Hua;ZHANG Xin [1]Sheng;WANG [1]Jin;YU Xiao [1]Ming;ZHANG Rong [1]Xin;XUE [2]Chao;YANG Xue [1]Yan;XUE Chang [1]Yong 高影响力作者 机构地区：[1]Department of Nutrition, Chinese PLA General Hospital;[2]Peking University Health Science Center高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2015年第28卷第2期,共8页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(No.81172667 and No.81202203) 摘　　要：Objective To investigate activation of brown adipose tissue(BAT) stimulated by medium-chain triglyceride(MCT). Methods 30 Male C57BL/6J obese mice induced by fed high fat diet(HFD) were divided into 2 groups, and fed another HFD with 2% MCT or long-chain triglyceride(LCT) respectively for 12 weeks. Body weight, blood biochemical variables, interscapular brown fat tissue(IBAT) mass, expressions of m RNA and protein of beta 3-adrenergic receptors(β3-AR), uncoupling protein-1(UCP1), hormone sensitive lipase(HSL), protein kinase A(PKA), and adipose triglyceride lipase(ATGL) in IBAT were measured. Results Significant decrease in body weight and body fat mass was observed in MCT group as compared with LCT group(P<0.05) after 12 weeks. Greater increases in IBAT mass was observed in MCT group than in LCT group(P<0.05). Blood TG, TC, LDL-C in MCT group were decreased significantly, meanwhile blood HDL-C, ratio of HDL-C/LDL-C and norepinephrine were increased markedly. Expressions of m RNA and protein of β3-AR, UCP1, PKA, HSL, ATGL in BAT were greater in MCT group than in LCT group(P<0.05). Conclusion Our results suggest that MCT stimulated the activation of BAT, possible via norepinephrine pathway, which might partially contribute to reduction of the body fat mass in obese mice fed high fat diet. 关 键 词：褐色脂肪组织 中链甘油三酯 高脂饮食 小鼠 激活 诱导 喂食 激素敏感脂肪酶
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