Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

查看全文 作　　者：Jian [1,2]Zhang;Sha [1,2]Li;Lu [3]Li;Meng [1]Li;Chongye [1]Guo;Jun [4]Yao;Shuangli [1]Mi

机构地区：[1]Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences;[2]University of Chinese Academy of Sciences;[3]Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University;[4]State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua-Peking Center for Life Sciences,School of Life Sciences, Tsinghua University

出　　处：《Genomics, Proteomics & Bioinformatics》索引2015年第13卷第1期,共8页

基　　金：supported by the Projects of International Cooperation and Exchanges from the National Natural Science Foundation of China(Grant No.31161120358);the National Basic Research Program from the Ministry of Science and Technology of China(973 program;Grant Nos20111CB510106 and 2015CB910603);the Open Project of State Key Laboratory of Biomembrane and Membrane Biotechnology;the Scientific Research Foundation for Returned Scholars from the Ministry of Education of China;ML was supported by National Natural Science Foundation of China(Grant No.31400741) 摘　　要：Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently,m RNAs and micro RNAs(mi RNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal mi RNAs, since the mi RNA profiles of exosomes may differ from those of the parent cells. Exosomal mi RNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal mi RNAs, and briefly describe how exosomes and their mi RNAs function in recipient cells.Finally, we will discuss the potential applications of these mi RNA-containing vesicles in clinical settings. 关键词：微RNA 排序纳米尺寸受体细胞细胞外 C100 核糖核酸血管生成

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Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

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