Noise-induced bistable switching dynamics through a potential energy landscape

查看全文 作　　者：Yuanhong [1,2]Bi;Zhuoqin [1]Yang;Xiangying [3]Meng;Qishao [4]Lu

机构地区：[1]School of Mathematics and Systems Science and LMIB,Beihang University, Beijing 100191, China;[2]School of Statistics and Mathematics, Inner MongoliaUniversity of Finance and Economics, Hohhot 010070, China;[3]Department of Biology, College Park University of Maryland,Maryland 20742, USA;[4]Department of Dynamics and Control, Beihang University,Beijing 100191, China

出　　处：《Acta Mechanica Sinica》索引2015年第31卷第2期,共7页

基　　金：supported by the National Natural Science Foundation of China(Grants 11372017,11272024,and 11371046);the General Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region(Grant NJZY14130) 摘　　要：Interlinked positive feedback loops,an important building block of biochemical systems,can induce bistable switching,leading to long-lasting state changes by brief stimuli.In this work,prevalent mutual activation between two species as another positive feedback is added to a generic interlinked positive-feedback-loop model originating from many realistic biological circuits.A stochastic fluctuation of the positive feedback strength is introduced in a bistable interval of the feedback strength,and bistability appears for the moderate feedback strength at a certain noise level.Stability analysis based on the potential energy landscape is further utilized to explore the noise-induced switching behavior of two stable steady states. 关键词：双稳态开关切换稳定性分析噪音景观势能反馈强度组成部分

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Noise-induced bistable switching dynamics through a potential energy landscape

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