The PI3K/AKT Pathway and Renal Cell Carcinoma

查看全文 作　　者：Huifang [1]Guo;Peter [2]German;Shanshan [2]Bai;Sean [1]Barnes;Wei [1]Guo;Xiangjie [3]Qi;Hongxiang [4]Lou;Jiyong [1]Liang;Eric [2]Jonasch;Gordon [1]B.Mills;Zhiyong [1]Ding

机构地区：[1]Department of Systems Biology,The University of Texas MD Anderson Cancer Center;[2]Department of Genitourinary Medical Oncology,The University of Texas MD Anderson Cancer Center;[3]Department of Radiation Oncology,People's Hospital of Linzi District;[4]Department of Natural Products Chemistry,Key Laboratory of Chemical Biology of Ministry of Education,School of Pharmaceutical Sciences,Shandong University

出　　处：《Journal of Genetics and Genomics》索引2015年第42卷第7期,共11页

基　　金：supported by the grant from The University of Texas MD Anderson Cancer Center Kidney Cancer Multidisciplinary Research Program to ZD;the NCI CCSG grant(No. P30 CA016672);the GDAC grant(No.5U24CA143883) 摘　　要：The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. 关键词：信号通路癌症治疗肾细胞磷脂酰肌醇3激酶碾压混凝土基因组测序 RCC 生长因子

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The PI3K/AKT Pathway and Renal Cell Carcinoma

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