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Mechanisms responsible for the effect of median nerve electrical stimulation on traumatic brain injuryinduced coma: orexin-A-mediated N-methyl-Daspartate receptor subunit NR1 upregulation

查看全文 作　　者：Zhen [1]Feng;Qing [1]Du 高影响力作者 机构地区：[1]Department of Rehabilitation, the First Affiliated Hospital of Nanchang University高影响力机构 出　　处：《Neural Regeneration Research》索引2016年第11卷第6期,共6页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China,No.81260295;the Natural Science Foundation of Jiangxi Province of China,No.20132BAB205063 摘　　要：Electrical stimulation of the median nerve is a noninvasive technique that facilitates awakening from coma. In rats with traumatic brain injury-induced coma, median nerve stimulation markedly enhances prefrontal cortex expression of orexin-A and its receptor, orexin receptor 1. To further understand the mechanism underlying wakefulness mediated by electrical stimulation of the median nerve, we evaluated its effects on the expression of the N-methyl-D-aspartate receptor subunit NR1 in the prefrontal cortex in rat models of traumatic brain injury-induced coma, using immunohistochemistry and western blot assays. In rats with traumatic brain injury, NR1 expression increased with time after injury. Rats that underwent electrical stimulation of the median nerve(30 Hz, 0.5 ms, 1.0 m A for 15 minutes) showed elevated NR1 expression and greater recovery of consciousness than those without stimulation. These effects were reduced by intracerebroventricular injection of the orexin receptor 1 antagonist SB334867. Our results indicate that electrical stimulation of the median nerve promotes recovery from traumatic brain injury-induced coma by increasing prefrontal cortex NR1 expression via an orexin-A-mediated pathway. 关 键 词：N-甲基-D-天冬氨酸受体 创伤性脑损伤 正中神经 电刺激 昏迷 机制 亚单位 额叶皮层
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