One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients

查看全文 作　　者：Zhifeng [1]Xiao;Fengwu [2]Tang;Jiaguang [3]Tang;Huilin [4]Yang;Yannan [1]Zhao;Bing [1]Chen;Sufang [1]Han;Nuo [1]Wang;Xing [1]Li;Shixiang [2]Cheng;Guang [2]Han;Changyu [2]Zhao;Xiaoxiong [3]Yang;Yumei [5]Chen;Qin [4]Shi;Shuxun [3]Hou;Sai [2]Zhang;Jianwu [1]Dai

机构地区：[1]State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences;[2]Department of Orthopaedics, First Affiliated Hospital of People’s Liberation Army (PLA) General Hospital;[3]Neurology and Neurosurgery Hospital, Affiliated Hospital of Logistics University of Chinese People’s Armed Police Forces (CAPF);[4]Department of Orthopaedics, The First Affiliated Hospital of Soochow University;[5]Department of Nerve Electrophysiology, First Affiliated Hospital of People’s Liberation Army (PLA) General Hospital

出　　处：《Science China(Life Sciences)》索引2016年第59卷第7期,共9页

基　　金：supported by grants from the 'Stem Cell and Regenerative Medicine Strategic Priority Research Program of the Chinese Academy of Sciences' (Grant No. XDA01030000);the Key Research Program of the Chinese Academy of Sciences (Grant No. ZDRW-ZS-2016-2) 摘　　要：The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI. 关键词：脊髓损伤瘢痕支架患者临床慢性骨髓单个核细胞神经组织

相关文献

参考文献（42）
引证文献（21）
耦合文献（18）

参考文献(42)

引证文献(21)

耦合文献(18)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients

参考文献(42)

引证文献(21)

耦合文献(18)

用户提示