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Identifying and annotating human bifunctional RNAs reveals their versatile functions

查看全文 作　　者：Geng [1]Chen;Juan [2]Yang;Jiwei [2]Chen;Yunjie [1]Song;Ruifang [2]Cao;Tieliu [2]Shi;Leming [1,3,4,5]Shi 高影响力作者 机构地区：[1]Center for Pharmacogenomics,School of Pharmacy and School of Life Sciences,Fudan University,Shanghai 201203,China;[2]The Center for Bioinformatics and Computational Biology,Shanghai Key Laboratory of Regulatory Biology,the Institute of Biomedical Sciences and School of Life Sciences,East China Normal University,Shanghai 200241,China;[3]State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology,School of Life Sciences,Fudan University,Shanghai 201203,China;[4]Fudan-Zhangjiang Center for Clinical Genomics,Shanghai 201203,China;[5]Zhanjiang Center for Translational Medicine,Shanghai 201203,China高影响力机构 出　　处：《Science China(Life Sciences)》索引2016年第59卷第10期,共12页高影响力期刊 基　　金：supported in part by the National High Technology Research and Development Program of China(2015AA020104,2015AA020108);the China Human Proteomics Project(2014DF30030);the National Science Foundation of China(31471239) 摘　　要：Bifunctional RNAs that possess both protein-coding and noncoding functional properties were less explored and poorly understood. Here we systematically explored the characteristics and functions of such human bifunctional RNAs by integrating tandem mass spectrometry and RNA-seq data. We first constructed a pipeline to identify and annotate bifunctional RNAs,leading to the characterization of 132 high-confidence bifunctional RNAs. Our analyses indicate that bifunctional RNAs may be involved in human embryonic development and can be functional in diverse tissues. Moreover, bifunctional RNAs could interact with multiple miRNAs and RNA-binding proteins to exert their corresponding roles. Bifunctional RNAs may also function as competing endogenous RNAs to regulate the expression of many genes by competing for common targeting miRNAs. Finally,somatic mutations of diverse carcinomas may generate harmful effect on corresponding bifunctional RNAs. Collectively,our study not only provides the pipeline for identifying and annotating bifunctional RNAs but also reveals their important gene-regulatory functions. 关 键 词：miRNAs 人类胚胎 识别 注释 多功能 蛋白相互作用 调控功能 蛋白质编码
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