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Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases

查看全文 作　　者：Yuan [1]Li;Xinyu [1]Bi;Jianjun [1]Zhao;Zhen [1]Huang;Jianguo [1]Zhou;Zhiyu [1]Li;Yefan [1]Zhang;Hong [1]Zhao;Jianqiang [1]Cai 高影响力作者 机构地区：[1]Department of Abdominal Surgery,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College高影响力机构 出　　处：《Chinese Journal of Cancer Research》索引2016年第28卷第5期,共8页高影响力期刊 基　　金：supported by the National High-Tech R&D Program (863 Program) of China (2015AA020408);the National Natural Science Foundation of China (81201967, 31470073);the Beijing Natural Science Foundation (7132193, 7144238);the Capital Health Research and Development of Special (2014-1-4022);Beijing Nova Program (No.2009A69) 摘　　要：Objective: The safety of the simultaneous resection of synchronous colorectal cancer liver metastases(SCRLM) is still being debated.However, this simultaneous operative approach is more commonly adopted at present than in the past.Therefore, we compared simultaneous hepatic resection with delayed hepatic resection in this study.Methods: All patients with SCRLM diagnosed before initial treatment between January 2009 and September 2013 were retrospectively included in our study.Short-term and long-term outcomes were compared in patients who underwent simultaneous colorectal and hepatic resection and those treated by delayed hepatectomy.Results: Among the 73 patients diagnosed with SCRLM, simultaneous colorectal and hepatic resection was performed in 60 patients(82.2%), while delayed hepatic resection was performed in 13 patients(17.8%).The mortality rate was zero.The postoperative complication rate after delayed resection was higher than, but not significantly different from, that after simultaneous resection(46% vs.23%, P=0.166).The duration of operating time(240 vs.420 min, P<0.05) and postoperative hospital stay time(11 vs.18 days, P<0.05) were shorter in the simultaneous resection group.After the initial treatments were given, the 1-, 2-, and 3-year survival rates in the simultaneous resection group were 77%, 59%, and 53%, respectively, whereas those in the delayed resection group were 67%, 42%, and 10%, respectively.The 5-year survival rate in the simultaneous resection group was 23%; overall survival differed significantly between the two groups(P=0.037).Median disease-free survival(DFS) times were 19.1 months in the simultaneous resection group and 8.8 months in the delayed resection group.DFS differed significantly between the two groups.Conclusions: Simultaneous colorectal and hepatic resection is safe and exhibits advantages in the longtime survival of patients. 关 键 词：Colorectal cancer synchronous liver metastases simultaneous resection SURVIVAL
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