CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy

查看全文 作　　者：Xiaohui [1]Zhang;Liren [1]Wang;Mingyao [1]Liu;Dali [1]Li

机构地区：[1]Shanghai Key Laboratory of Regulatory Biology, institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China

出　　处：《Science China(Life Sciences)》索引2017年第60卷第5期,共8页

基　　金：supported by the National Natural Science Foundation of China (31371455, 31171318 to Dali Li, 81330049 to Mingyao Liu);the Science and Technology Commission of Shanghai Municipality (14140900300 to Dali Li) 摘　　要：CRISPR/Cas9 is a versatile genome-editing tool which is widely used for modifying the genome of both prokaryotic and eukaryotic organisms for basic research and applications. An increasing number of reports have demonstrated that CRISPR/Cas9-mediated genome editing is a powerful technology for gene therapy. Here, we review the recent advances in CRISPR/Cas9-mediated gene therapy in animal models via different strategies and discuss the challenges as well as future prospects. 关键词：基因治疗技术生物基因组系统体外体内编辑工具基础研究

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CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy

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