Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis

查看全文 作　　者：Xin-zhi [1]Sun;Ying [2,3]Liao;Wei [2]Li;Li-mei [3]Guo

机构地区：[1]Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University;[2]Department of Public Security Technology, Railway Police College;[3]Department of Pathology, Peking University Health Science Center

出　　处：《Neural Regeneration Research》索引2017年第12卷第6期,共6页

摘　　要：Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Hydrogen peroxide(H_2O_2) was used to induce apoptosis in cultured cerebellar granule cells. In these cells, ganoderma lucidum polysaccharides remarkably suppressed H_2O_2-induced apoptosis, decreased expression of caspase-3, Bax and Bim and increased that of Bcl-2. These findings suggested that ganoderma lucidum polysaccharides regulate expression of apoptosis-associated proteins, inhibit oxidative stress-induced neuronal apoptosis and, therefore, have significant neuroprotective effects. 关键词：神经保护作用灵芝多糖氧化应激神经元凋亡诱导 CASPASE-3 小脑颗粒细胞

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Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis

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