Transcription Factors:Potential Cell Death Markers in Parkinson's Disease

查看全文 作　　者：Ronglin [1]Wang;Shaosong [1]Yang;Tiejian [1]Nie;Gang [1]Zhu;Dayun [1]Feng;Qian [1]Yang

机构地区：[1]Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China

出　　处：《Neuroscience Bulletin》索引2017年第33卷第5期,共9页

基　　金：supported by the National Key Research and Development Program of China (2016YFC1306603);the National Natural Science Foundation of China (31671060) 摘　　要：Parkinson's disease(PD) is a neurodegenerative disease with a long preclinical phase. The continuous loss of dopaminergic(DA) neurons is one of the pathogenic hallmarks of PD. Diagnosis largely depends on clinical observation, but motor dysfunctions do not emerge until70%–80% of the nigrostriatal nerve terminals have been destroyed. Therefore, a biomarker that indicates the degeneration of DA neurons is urgently needed. Transcription factors are sequence-specific DNA-binding proteins that regulate RNA synthesis from a DNA template. The precise control of gene expression plays a critical role in the development, maintenance, and survival of cells,including DA neurons. Deficiency of certain transcription factors has been associated with DA neuron loss and PD. In this review, we focus on some transcription factors and discuss their structure, function, mechanisms of neuroprotection, and their potential for use as biomarkers indicating the degeneration of DA neurons. 关键词：帕金森病转录因子细胞死亡多巴胺能神经元神经变性疾病标志物 DNA结合蛋白生物标记物

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Transcription Factors:Potential Cell Death Markers in Parkinson's Disease

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