The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers

查看全文 作　　者：YANG Ting [1]Ting;LIU Chen [1]Geng;GAO Shi [1]Chao;ZHANG [1]Yi;WANG Pei [1]Chang

机构地区：[1]Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University

出　　处：《Biomedical and Environmental Sciences》索引2018年第31卷第2期,共10页

基　　金：supported by the National Key Research and Development Program of China[2016YFC1306300];the National Natural Science Foundation of China[No.81401734];the National Research Foundation for the Doctoral Program of Higher Education of China[No.20121107110001];the National Natural Science Foundation of China[No.81472007] 摘　　要：Objective MicroR NAs(mi Rs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease(AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. Methods The expression levels of exosomal miR-135 a,-193 b, and-384 in the serum from mild cognitive impairment(MCI), dementia of Alzheimer-type(DAT), Parkinson's disease with dementia(PDD), and vascular dementia(VaD) patients were measured with a real-time quantitative reverse transcriptase PCR(qR T-PCR) method. Results Both serum exosome mi R-135 a and miR-384 were up-regulated while miR-193 b was down-regulated in serum of AD patients compared with that of normal controls. Exosome miR-384 was the best among the three miR s to discriminate AD, VaD, and PDD. Using the cut-off value could better interpret these laboratory test results than reference intervals in the AD diagnosis. ROC curve showed that the combination of mi R-135 a,-193 b, and-384 was proved to be better than a particular one for early AD diagnosis. Conclusion Our results indicated that the exosomal miR s in the serum were not only potential biomarker of AD early diagnosis, but might also provide novel insights into the screen and prevention of the disease. 关键词：浆液疾病媒体控制接口实验室测试 PDD VAD 广告表达式

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The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers

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