Association of serum levels of perfluoroalkyl substances with gestational diabetes mellitus and postpartum blood glucose

查看全文 作　　者：Yuxin [1]Wang;Lei [1]Zhang;Yue [2]Teng;Jiayu [3]Zhang;Lin [1]Yang;Jingguang [1]Li;Jianqiang [4]Lai;Yunfeng [1]Zhao;Yongning [1]Wu

机构地区：[1]The Key Laboratory of Food Safety Risk Assessment, Ministry of Health (CFSA), China National Center for Food Safety Risk Assessment,Beijing 100021, China;[2]Haidian Maternal and Child Hygiene Hospital, Beijing 100080, China;[3]College of Literature, Science and Arts, University of Michigan, Ann Arbor, MI48104, USA;[4]National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China

出　　处：《Journal of Environmental Sciences》索引2018年第30卷第7期,共7页

基　　金：supported by the National Natural Science Foundation of China(Nos.21537001and 21477030);the National Key Research and Development Program of China(No.2017YFC1600502);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB14010100) 摘　　要：This study was conducted to examine the association of perfluoroalkyl substance(PFAS)exposure with gestational diabetes mellitus(GDM) risk and postpartum fasting blood glucose.We used a 1:2 matched case–control study with 84 GDM subjects and 168 healthy pregnant women from Beijing, China. The maternal blood was collected at 1–2 days before delivery, and eight linear isomers and fourteen branched isomers were determined in maternal serum.Logistic regression analyses were performed to evaluate the associations after adjusting for potential confounders. The median of the sum of levels of total PFASs was 4.24 ng/m L with a interquartile range(IQR) of 2.82–6.54 ng/m L. Although maternal PFAS exposure was not associated with risk of GDM, significant positive associations were observed between evaluated exposure to specific PFAS congeners and increasing blood glucose. The odds ratio(ORs) of the highest category of postpartum fasting blood glucose for perfluoro-1-metylheptylsulfonat(1 m-PFOS), perfluoro-3/4-metylheptylsulfonat(3 m+4 m-PFOS), perfluoro-5-metylheptylsulfonat(5 m-PFOS), and perfluorohexane sulfonate(PFHx S) were 2.03(95% CI: 1.09–3.77), 1.93(95% CI:1.04–3.58), 2.48(95% CI: 1.33–4.65), and 2.26(95% CI: 1.21–4.21), respectively, suggesting negative effects of maternal exposure to specific PFAS compounds on glucose metabolism. 关键词：葡萄糖糖尿病协会产后物质浆液回归分析新陈代谢

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Association of serum levels of perfluoroalkyl substances with gestational diabetes mellitus and postpartum blood glucose

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