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Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation

查看全文 作　　者：Xueying [1]Zhang;Hongliang [2]Tian;Lili [1]Gu;Yongzhan [3]Nie;Chao [1,4]Ding;Xiaolong [1,5]Ge;Bo [2]Yang;Jianfeng [1]Gong;Ning [1,2]Li 高影响力作者 机构地区：[1]Department of General Surgery, Jinling Hospital, Medical School of Nanjing University;[2]Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University;[3]Institute of Digestive Diseases, Xi Jing Hospital, Fourth Military Medical University;[4]Department of General Surgery, Drum Tower Hospital, Medical School of Nanjing University;[5]Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine高影响力机构 出　　处：《Science China(Life Sciences)》索引2018年第61卷第7期,共8页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China (81670493);by the National Gastroenterology Research Project (2015BAI13B07) 摘　　要：As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. 关 键 词：治疗学 便秘 纤维 饮食 运输 移植 FMT STC
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