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Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines

查看全文 作　　者：Shan-Shan [1,2]Rao;Yin [1,3]Hu;Ping-Li [4]Xie;Jia [1]Cao;Zhen-Xing [1]Wang;Jiang-Hua [1,3]Liu;Hao [1,3]Yin;Jie [1,3]Huang;Yi-Juan [1]Tan;Juan [1]Luo;Ming-Jie [5]Luo;Si-Yuan [5]Tang;Tuan-Hui [1]Chen;Ling-Qing [6]Yuan;Er-Yuan [6]Liao;Ran [6]Xu;Zheng-Zhao [1]Liu;Chun-Yuan [1]Chen;Hui [3,7,8,9,10]Xie 高影响力作者 机构地区：[1]Movement System Injury and Repair Research Center,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China;[2]Department of Spine Surgery,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China;[3]Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China;[4]Department of Forensic Science,School of Basic Medical Sciences,Central South University,Changsha,Hunan 410013,China;[5]Xiangya Nursing School,Central South University,Changsha,Hunan 410013,China;[6]Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China;[7]Hunan Key Laboratory of Organ Injury,Aging and Regenerative Medicine,Changsha,hunan 410008,China;[8]Department of Sports Medicine,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China;[9]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China;[10]China Orthopedic Regenerative Medicine Group(CORMed),Changsha,Hunan,China高影响力机构 出　　处：《Bone Research》索引2018年第6卷第2期,共12页高影响力期刊 基　　金：supported by the Excellent Young Scientist Foundation of the National Natural Science Foundation of China(Grant No.81522012);the National Natural Science Foundation of China(Grant No.81670807,81600699,81702237,81701383,81400858);the Thousand Youth Talents Plan of China(Grant No.D1119003);the Hunan Youth Talent Project(Grant No.2016RS3021);the Innovation Driven Project of Central South University(2016CX028);the Youth Foundation of Xiangya Hospital in Central South University(Grant No.2016Q10);the Fundamental Research Funds for the Central Universities of Central South University(Grant No.2017zzts032,2017zzts014);the Hunan Province Natural Science Foundation of China(Grant No.2017JJ3501);the China Postdoctoral Science Foundation(Grant No.2017M612596);the Natural Science Foundation for Distinguished Yong Scholars of Guangdong Province(2016A030306051);the National Basic Research Program of China(973 Program,Grant no.2014CB942903) 摘　　要：Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone formation. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about the role of omentin-1 in inflammatory osteoporosis. Here we generated global omentin-1 knockout(omentin-1^(-/-)) mice and demonstrated that depletion of omentin-1 induces inflammatory bone loss-like phenotypes in mice, as defined by abnormally elevated pro-inflammatory cytokines, increased osteoclast formation and bone tissue destruction, as well as impaired osteogenic activities. Using an inflammatory cell model induced by tumor necrosis factor-α(TNF-α), we determined that recombinant omentin-1 reduces the production of proinflammatory factors in the TNF-α-activated macrophages, and suppresses their anti-osteoblastic and pro-osteoclastic abilities. In the magnesium silicate-induced inflammatory osteoporosis mouse model, the systemic administration of adenoviral-delivered omentin-1 significantly protects from osteoporotic bone loss and inflammation. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of inflammatory bone diseases by downregulating the proinflammatory cytokines. 关 键 词：CYTOKINES 骨质疏松症 巨噬细胞 骨头 并发症 损失 老鼠 硅酸盐
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