Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis

查看全文 作　　者：Xiaoying [1,2]Fan;Ji [1,2]Dong;Suijuan [3,4,5]Zhong;Yuan [1,6]Wei;Qian [3,4,5]Wu;Liying [1,6]Yan;Jun [1,6]Yong;Le [3,4,5]Sun;Xiaoye [1,6]Wang;Yangyu [1,6]Zhao;Wei [1,6]Wang;Jie [1,6]Yan;Xiaoqun [3,4,5,7]Wang;Jie [1,6,8,9]Qiao;Fuchou [1,2,9]Tang

机构地区：[1]Beijing Advanced Innovation Center for Genomics, Department of Obstetrics and Gynecology, College of Life Sciences, Third Hospital, Peking University, Beijing 100871, China;[2]Biomedical Institute for Pioneering Investigation via Convergence and Center for Reproductive Medicine, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 100871, China;[3]State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology; Institute of Brain-Intelligence Science and Technology Zhangjiang Laboratory (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;[4]University of Chinese Academy of Sciences, Beijing 100049, China;[5]Shanghai Center for Brain Science and Intelligence Technology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;[6]Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing 100191, China;[7]Beijing Institute for Brain Disorders, Beijing 100069, China;[8]Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China;[9]Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China

出　　处：《Cell Research》索引2018年第28卷第7期,共16页

基　　金：This study was supported by the National Natural Science Foundation of China (31625018, 81561138005, 31230047, 81521002 and 91732301), the National Basic Research Program of China (2014CB964600 and 2017YFA0103303), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16020601), Shanghai Brain-lntelligence Project from STCSM (16JC1420500), and the Beijing Advanced Innovation Center for Genomics at Peking University. High-throughput sequencing was performed in Novogene. 摘　　要：人的大脑开发的细胞的复杂性强烈地被调查了,尽管全部人的服的外皮的地区性的描述没基于单个房间的 transcriptome 分析被报导。这里,我们从人的中间怀孕期的胚胎的 22 个大脑区域在超过 4,000 个单个房间上执行了 RNA-seq。我们识别了 29 房间亚簇,它证明在每个区域和脑桥的不同比例显示出星形细胞的特别高的百分比。胚胎的神经原不象成年神经原一样多样,尽管他们在成年人拥有了他们的命运的重要特征。神经原开发是在服的外皮的 unsynchronized,当背面的区域看起来比在这个阶段的腹的区域更成熟。区域特定的基因包括地在每 neuronal 亚簇被识别,并且这些基因的一个大比例是联系的神经疾病。我们的结果介绍区域化的基因表示的一处系统的风景和人的服的外皮的神经原成熟。 关键词：房间外皮胚胎空间大脑开发星形细胞神经原成年人

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Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis

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