维普中文期刊产品整合服务

Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation

查看全文 作　　者：Junbo [1,2]Gao;Xingjie [1]Zhang;Kun [1]Shang;Weimao [2]Zhong;Ruihan [1]Zhang;Xiaochang [1]Dai;Xiaoli [1]Li;Qi [1]Wang;Yan [1]Zou;Weilie [1]Xiao 高影响力作者 机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education and Yunnan Province,School of Chemical Science and Technology,Yunnan University,Kunming 650091,China;[2]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China高影响力机构 出　　处：《Chinese Chemical Letters》索引2020年第31卷第2期,共4页高影响力期刊 基　　金：financially supported by the National Natural Science Foundation of China(Nos.81422046 and 21762048);the Yunnan Applicative and Basic Research Program(Nos.2015BC002,2018FY001 and 2018FA048);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94);the Key Program of Natural Science of Yunnan Province to W.L.Xiao;the Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education(No.2017KF02);the Natural Science Foundation of Yunnan University(No.2017YDQN03);the Foundation of Yunnan Educational Committee(No.2018JS002)。 摘　　要：Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro. 关 键 词：CALLICARPA bodinieri Abietane-type DITERPENOIDS DP4+NMR calculation Anti-inflammation PYROPTOSIS NLRP3 INFLAMMASOME
相关文献

参考文献(30)

引证文献(3)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费