Tumor-homing peptide-based NIR-II probes for targeted spontaneous breast tumor imaging

查看全文 作　　者：Hui [1,2]Zhou;Shanshan [2]Li;Xiaodong [2]Zeng;Mengxian [2]Zhang;Lin [2]Tang;Qianqian [2]Li;Deliang [4]Chen;Xianli [1]Meng;Xuechuan [1,2,3]Hong

机构地区：[1]Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine.Chengdu 611137,China;[2]Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE),Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals.Shenzhen Institute of Wuhan University,Shenzhen 518057,China;[3]College of Science,Innovation Center for Traditional Tibetan Medicine Modernization and Quality Control,Medical College,Tibet University,Lasa 850000,China;[4]Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry,Chemistry and Chemical Engineering College,Gannan Normal University,Ganzhou 341000,China

出　　处：《Chinese Chemical Letters》索引2020年第31卷第6期,共6页

基　　金：partially supported by grants from the National Natural Science Foundation of China(Nos.81773674,21473041 and 81573383);Project First-Class Disciplines Development Supported by Chengdu University of Traditional Chinese Medicine(No.CZYJC1903);Natural Science Foundation of Hubei Province(Nos.2017CFA024,2016ACA126 and 2017CFB711);the Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology(No.2019020701011429);Shenzhen Science and Technology Research Grant(No.JCYJ20190808152019182);Tibet Autonomous Region Science and Technology Plan Project Key Project(No.XZ201901-GB-11);the Fundamental Research Funds for the Central Universities,and Health Commission of Hubei Province Scientific Research Project(Nos.WJ2019M177 and WJ2019M178)。 摘　　要：Fluorescence imaging in the second near-infrared window(NIR-Ⅱ,1000-1700 nm)is a promising modality for real-time imaging of cancer and image-guided surgery with superior in vivo optical properties.So far,very few NIR-Ⅱfluorophores have been reported for in vivo biomedical imaging of chemically-induced spontaneous breast carcinoma.Herein,a NIR-Ⅱfluorescent probe CH1055-F3 with the nucleolin-targeted tumor-homing peptide F3 was demonstrated to prefe rentially accumulate in 4 T1 tumors.More importantly,CH1055-F3 exhibited specific NIR-Ⅱsignals with high spatial and temporal resolution,strong tumor uptake,and remarkable NIR-Ⅱimage-guided surgery in dimethylbenzanthracene(DMBA)-induced spontaneous breast tumor rats.This report presents the first tumor-homing peptide-based NIR-Ⅱprobe to diagnose transplantable and spontaneous breast tumors by the active targeting. 关键词：NIR-Ⅱimaging F3 peptide Image-guided surgery Spontaneous breast carcinoma NIR-Ⅱprobes

相关文献

参考文献（50）
引证文献（7）
耦合文献（0）

参考文献(50)

引证文献(7)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Tumor-homing peptide-based NIR-II probes for targeted spontaneous breast tumor imaging

参考文献(50)

引证文献(7)

用户提示