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Nanoliposome-encapsulated caged-GABA for modulating neural electrophysiological activity with simultaneous detection by microelectrode arrays

查看全文 作　　者：Jingyu [1,2]Xie;Yilin [1,2]Song;Yuchuan [1,2]Dai;Ziyue [1,2]Li;Fei [1,2]Gao;Xuanyu [2,3]Li;Guihua [1,2]Xiao;Yu [1,2]Zhang;Hao [1,2]Wang;Zeying [1,2]Lu;Xingyu [3,4]Jiang;Wenfu [3]Zheng;Xinxia [1,2]Cai 高影响力作者 机构地区：[1]State Key Laboratory of Transducer Technology,Institute of Electronics,Chinese Academy of Sciences,Beijing,100190,China;[2]University of Chinese Academy of Sciences,Beijing,100049,China;[3]Beijing Engineering Research Center for BioNanotechnology,CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for NanoScience and Technology,Beijing,100190,China;[4]Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China高影响力机构 出　　处：《Nano Research》索引2020年第13卷第6期,共8页高影响力期刊 基　　金：This work was sponsored by the National Key Research and Development Program of nano science and technology of China (No. 2017YFA0205902);the National Natural Science Foundation of China (Nos. 61527815, 61960206012, 61975206, 61775216, 61971400, 61973292 and 61771452);the Key Research Programs (Nos. QYZDJ-SSW-SYS015 and XDA16020902) of Frontier Sciences, CAS. 摘　　要：Effective and precise neural modulation with real-time detection in the brain is of great importance and represents a significant challenge.Nanoliposome-encapsulated light-sensitive compounds have excellent characteristics such as high temporal and spatial resolution,delayed drug clearance,and restricted drug biodistribution for neural modulation.In this study,we developed a nanoliposome-based delivery system for ruthenium-based caged GABA compounds(Nanolipo-Ru)to modulate neural activity and allow for real-time monitoring using the microelectrode arrays(MEAs).The Nanolipo-Ru nanoparticles had an average size of 134.10±4.30 nm and exhibited excellent stability for seven weeks.For the in vivo experiment in the rat,release of GABA by Nanolipo-Ru under blue light illumination resulted in an average firing rate reduction in interneurons and pyramidal neurons in the same brain region of 79.4%and 81.6%,respectively.Simultaneously,the average power of local field potentials in the 0–15 Hz range degraded from 4.34 to 0.85 mW.In addition,the Nanolipo-Ru nanoparticles have the potential to provide more flexible timing of modulation than unencapsulated RuBi-GABA in the experiments.These results indicated that Nanolipo-Ru could be an effective platform for regulating neuronal electrophysiology.Furthermore,nanoliposomes with appropriate modifications would render promising utilities for targeting of specific types of neurons in the future. 关 键 词：neural modulation nanoliposome microelectrode array light-sensitive drug
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