A targeting black phosphorus nanoparticle based immune cells nanoregulator for photodynamic/photothermal and photo-immunotherapy

查看全文 作　　者：Xiaoge [1]Zhang;Junjie [1]Tang;Chao [1]Li;Yao [1]Lu;Lili [1]Cheng;Jie [1]Liu

机构地区：[1]School of Biomedical Engineering,Sun Yat-sen University,Guangzhou,Guangdong 510006,China

出　　处：《Bioactive Materials》索引2021年第6卷第2期,共18页

基　　金：This work was supported by the National Natural Science Foundation of China(51773231);the Natural Science Foundation of Guangdong Province(2014A030312018,2016A030313315);the Project of Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province(2011A060901013). 摘　　要：Photo-immunotherapy is a novel therapeutic approach against malignant tumors with minimal invasiveness.Herein,a targeting multifunctional black phosphorus(BP)nanoparticle,modified by PEGylated hyaluronic acid(HA),was designed for photothermal/photodynamic/photo-immunotherapy.In vitro and in vivo assays indicated that HA-BP nanoparticles possess excellent biocompatibility,stability,and sufficient therapeutic efficacy in the combined therapy of photothermal therapy(PTT)and photodynamic therapy(PDT)for cancer therapy.Moreover,the results of in vitro showed that HA-BP down-regulated the expression of CD206(M2 macrophage marker)by 42.3%and up-regulated the ratio of CD86(M1 macrophage marker)by 59.6%,indicating that HABP nanoparticles have functions in remodeling tumor associated macrophages(TAMs)phenotype(from protumor M2 TAMs to anti-tumor M1 macrophages).Fluorescence(FL)and photoacoustic(PA)multimodal imaging confirmed the selective accumulation of HA-BP in tumor site via both CD44^+mediated active targeting and passive EPR effect.In vitro and in vivo studies suggested that the combined therapy of PDT,PTT and immunotherapy using HA-BP could not only significantly inhibit original tumor but also induce immunogenic cell death(ICD)and release Damage-associated molecular patterns(DAMPs),which could induce maturation of dendritic cells(DCs)and activate effector cells that robustly evoke the antitumor immune responses for cancer treatment.This study expands the biomedical application of BP nanoparticles and displays the potential of modified BP as a multifunctional therapeutic platform for the future cancer therapy. 关键词：Black phosphorus Tumor associated macrophages Photothermal therapy Photodynamic therapy IMMUNOTHERAPY

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A targeting black phosphorus nanoparticle based immune cells nanoregulator for photodynamic/photothermal and photo-immunotherapy

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