Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses

查看全文 作　　者：Jianlin [1,2]Zhang;Xuehui [3]Chen;Juanji [4]Hong;Aifa [2]Tang;Yang [2]Liu;Ni [1]Xie;Guohui [2]Nie;Xiyun [3]Yan;Minmin [4]Liang

机构地区：[1]Guangdong Provincial Key Laboratory of Brain Function and Disease,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China;[2]Institute of Post-transcriptional Medicine,Shenzhen Second People’s Hospital,The First Affiliatied Hospital of Shenzhen University,Health Science Center,Shenzhen 518035,China;[3]CAS Engineering Laboratory for Nanozyme,Key Laboratory of Protein and Peptide Pharmaceutical,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;[4]Experimental Center of Advanced Materials,School of Materials Science&Engineering,Beijing Institute of Technology,Beijing 100081,China

出　　处：《Science China(Life Sciences)》索引2021年第64卷第3期,共11页

基　　金：Sanming Project of Medicine in Shenzhen(SZSM201612031);the National Natural Science Foundation of China(81722024,81772736,81571728);Chinese Academy of Sciences(YJKYYQ20180048);the Basic Research Foundation for Shenzhen’s Science and Technology(20190726095103499);the National Key Research and Development Program of China(2017YFA0205501,2017YFA0205503);the Youth Innovation Promotion Association(2014078). 摘　　要：Ferritin,an iron-storage protein,regulates cellular iron metabolism and oxidative stress.The ferritin structure is characterized as a spherical cage,inside which large amounts of iron are deposited in a safe,compact and bioavailable form.All ferritins readily catalyze Fe(II)oxidation by peroxides at the ferroxidase center to prevent free Fe(II)from participating in oxygen free radical formation via Fenton chemistry.Thus,ferritin is generally recognized as a cytoprotective stratagem against intracellular oxidative damage.The expression of cytosolic ferritins is usually regulated by iron status and oxidative stress at both the transcriptional and post-transcriptional levels.The mechanism of ferritin-mediated iron recycling is far from clarified,though nuclear receptor co-activator 4(NCOA4)was recently identified as a cargo receptor for ferritin-based lysosomal degradation.Cytosolic ferritins are heteropolymers assembled by H-and L-chains in different proportions.The mitochondrial ferritins are homopolymers and distributed in restricted tissues.They play protective roles in mitochondria where heme-and Fe/S-enzymes are synthesized and high levels of ROS are produced.Genetic ferritin disorders are mainly related to the L-chain mutations,which generally cause severe movement diseases.This review is focused on the biochemistry and function of mammalian intracellular ferritin as the major iron-storage and anti-oxidation protein. 关键词：FERRITIN iron homeostasis oxidative responses ANTIOXIDANT Fenton reaction

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Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses

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引证文献(13)

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