Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution

查看全文 作　　者：Weimin [1]Lin;Qiwen [1]Li;Danting [1]Zhang;Xiaohan [1]Zhang;Xingying [1]Qi;Qian [1]Wang;Yaqian [1]Chen;Caojie [1]Liu;Hanwen [1]Li;Shiwen [1,2]Zhang;Yuan [1]Wang;Bin [1]Shao;Li [3]Zhang;Quan [1,2]Yuan

机构地区：[1]State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,China;[2]Department of Oral Implantology,West China Hospital of Stomatology,Sichuan University,Chengdu,China;[3]Department of Respiratory and Critical Care Medicine,Frontiers Science Center for Disease-related Molecular Network,Center of Precision Medicine,Precision Medicine Key Laboratory of Sichuan Province,West China Hospital,Sichuan University,Chengdu,China

出　　处：《Bone Research》索引2021年第9卷第1期,共12页

基　　金：the National Natural Science Foundation of China(NSFC 81722014,81970913);State Key Laboratory of Oral Diseases(SKLOD202008);West China Hospital of Stomatology(RD-03-202010). 摘　　要：Alveolar bone is the thickened ridge of jaw bone that supports teeth.It is subject to constant occlusal force and pathogens invasion,and is therefore under active bone remodeling and immunomodulation.Alveolar bone holds a distinct niche from long bone considering their different developmental origin and postnatal remodeling pattern.However,a systematic explanation of alveolar bone at single-cell level is still lacking.Here,we construct a single-cell atlas of mouse mandibular alveolar bone through single-cell RNA sequencing(scRNA-seq).A more active immune microenvironment is identified in alveolar bone,with a higher proportion of mature immune cells than in long bone.Among all immune cell populations,the monocyte/macrophage subpopulation most actively interacts with mesenchymal stem cells(MSCs)subpopulation.Alveolar bone monocytes/macrophages express a higher level of Oncostatin M(Osm)compared to long bone,which promotes osteogenic differentiation and inhibits adipogenic differentiation of MSCs.In summary,our study reveals a unique immune microenvironment of alveolar bone,which may provide a more precise immune-modulatory target for therapeutic treatment of oral diseases. 关键词：ALVEOLAR MANDIBULAR HOMEOSTASIS

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Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution

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