Novel application of bergapten and quercetin with anti-bacterial,osteogenesis-potentiating,and anti-inflammation tri-effects

查看全文 作　　者：Jianxu [1]Wei;Xiaomeng [1]Zhang;Yuan [1]Li;Xinxin [1]Ding;Yi [1]Zhang;Xue [1]Jiang;Hongchang [1]Lai;Junyu [1]Shi

机构地区：[1]Department of Oral and Maxillo-facial Implantology,Shanghai Ninth People’s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200011,China

出　　处：《Acta Biochimica et Biophysica Sinica》索引2021年第53卷第6期,共14页

基　　金：supported by the grants from Natural Science Foundation of Shanghai([2020] 20ZR1431700);Fundamental Research Program Funding of Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(No.JYZZ102)。 摘　　要：The bacteria-mediated inflammatory conditions adversely affect the osseointegration process of endosseous implants,which can even lead to implant malfunction or failure.Local drug delivery has been designed to exert anti-inflammatory and antibacterial activities,but whether this strategy has an effect on the compromised osseointegration under inflammation has rarely been studied.The present study focused on the osteoinductive efficacy of two known phytoestrogens[bergapten(BP)and quercetin(QE)]on implant sites under multiple bacteria-infected conditions in situ.Furthermore,the gene expression profiles of rat bone mesenchymal stem cells(rBMSCs)treated with BP and QE in the presence of Porphyromonas gingivalis-derived lipopolysaccharide were identified.The results showed that both drugs,especially QE,had significant potentiating effects on promoting osteogenic differentiation of rBMSCs,resisting multiple pathogens,and reducing inflammatory activity.Meanwhile,RNA sequencing analysis highlighted the enriched gene ontology terms and the differentially expressed genes(Vps25,Il1r2,Csf3,Efemp1,and Ccl20)that might play essential roles in regulating the above tri-effects,which provided the basis for the drug delivery system to be used as a novel therapeutic strategy for integrating peri-implant health.Overall,our study confirmed that QE appeared to outperform BP in osteogenesis and bacterial killing but not in anti-inflammation.Moreover,both drugs possess favorable tri-effects and can serve as the pivotal agents for the drug delivery system to boost osseointegration at inflammatory implant sites. 关键词：QUERCETIN BERGAPTEN OSTEOGENESIS multispecies biofilm ANTI-INFLAMMATION

相关文献

参考文献（35）
引证文献（7）
耦合文献（0）

参考文献(35)

引证文献(7)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Novel application of bergapten and quercetin with anti-bacterial,osteogenesis-potentiating,and anti-inflammation tri-effects

参考文献(35)

引证文献(7)

用户提示