Recent advances in the development of nanomedicines for the treatment of ischemic stroke

查看全文 作　　者：Xing [1]Tian;Taojian [2]Fan;Wentian [1]Zhao;Ghulam [2]Abbas;Bo [1]Han;Ke [1]Zhang;Nan [2]Li;Ning [2]Liu;Weiyuan [2]Liang;Hao [2]Huang;Wen [1]Chen;Bing [2]Wang;Zhongjian [3]Xie

机构地区：[1]Key Laboratory of Xinjiang Phytomedicine Resource and Utilization,Ministry of Education,College of Pharmacy,Shihezi University,Shihezi,832002,China;[2]Institute of Microscale Optoelectronics,Collaborative Innovation Centre for Optoelectronic Science&Technology,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,College of Physics and Optoelectronic Engineering,Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology,Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ),Shenzhen University,Shenzhen,518060,PR China;[3]Shenzhen International Institute for Biomedical Research,518116,Shenzhen,Guangdong,China

出　　处：《Bioactive Materials》索引2021年第6卷第9期,共16页

基　　金：The research was partially supported by the National Natural Science Foundation of China(NSFC)(81960334,U1803128,81960648);Science and Technology Innovation Commission of Shenzhen(KQTD2015032416270385);Science and Technology Development Fund(STDF)(007/2017/A1);Macao SAR;China and the Postgraduate Innovation Development Fund Project of Shenzhen University(PIDFPZR2018004). 摘　　要：Ischemic stroke is still a serious threat to human life and health,but there are few therapeutic options available to treat stroke because of limited blood-brain penetration.The development of nanotechnology may overcome some of the problems related to traditional drug development.In this review,we focus on the potential applications of nanotechnology in stroke.First,we will discuss the main molecular pathological mechanisms of ischemic stroke to develop a targeted strategy.Second,considering the important role of the blood-brain barrier in stroke treatment,we also delve mechanisms by which the blood-brain barrier protects the brain,and the reasons why the therapeutics must pass through the blood-brain barrier to achieve efficacy.Lastly,we provide a comprehensive review related to the application of nanomaterials to treat stroke,including liposomes,polymers,metal nanoparticles,carbon nanotubes,graphene,black phosphorus,hydrogels and dendrimers.To conclude,we will summarize the challenges and future prospects of nanomedicine-based stroke treatments. 关键词：STROKE NANOMATERIALS Blood-brain barrier

相关文献

参考文献（277）
引证文献（6）
耦合文献（193）

参考文献(277)

引证文献(6)

耦合文献(193)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Recent advances in the development of nanomedicines for the treatment of ischemic stroke

参考文献(277)

引证文献(6)

耦合文献(193)

用户提示