Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and covaccination as an effective method of prevention of COVID-19 and influenza

查看全文 作　　者：Linlin [1]Bao;Wei [1]Deng;Feifei [1]Qi;Qi [1]Lv;Zhiqi [1]Song;Jiangning [1]Liu;Hong [1]Gao;Qiang [1]Wei;Pin [1]Yu;Yanfeng [1]Xu;Yajin [1]Qu;Fengdi [1]Li;Jing [1]Xue;Shuran [1]Gong;Mingya [1]Liu;Guanpeng [1]Wang;Shunyi [1]Wang;Binbin [1]Zhao;Bin [2]Cong;Chuan [1]Qin

机构地区：[1]Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases,NHC Key Laboratory of Human Disease Comparative Medicine,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center,Peking Union Medical College,Beijing,China;[2]Hebei Medical University,Shijiazhuang,China

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第6期,共8页

基　　金：supported by the CAMS Initiative for Innovative Medicine of China(Grant Nos.2020-I2M-COV19-009,2016-I2M-2-006,2018-I2M-1-003);the Special Funds of the National Natural Science Foundation of China(Grant No.82041035);the National Research and Development Project of China(Grant No.2020YFC0841100);the National Mega projects of China for Major Infectious Diseases(Grant Nos.2017ZX10304402,2018ZX10301403);the National Key Research and Development Project of China(Grant No.2016YFD0500304);the Fundamental Research Funds for the Central Public Welfare Research Institutes(Grant No.ZZ13-035-03). 摘　　要：Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus,leading to more serious respiratory diseases during this winter.However,the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear.Using a mammalian model,sequential infection was performed in ferrets and in K18-MCE2 mice,with SARS-CoV-2 infection following H1N1.We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19,and enhanced pulmonary damage,but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets.Moreover,mortality was increased in sequentially infected mice compared with single-infection mice.Compared with singlevaccine inoculation,co-inoculation of PiCoVacc(a SARS-CoV-2 vaccine)and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune responses.Combined immunization effectively protected K18-MCE2 mice against both H1N1 and SARS-CoV-2 infection.Our findings indicated the development of systematic models of co-infection of H1N1 and SARS-CoV-2,which together notably enhanced pneumonia in ferrets and mice,as well as demonstrated that simultaneous vaccination against HINT and SARS-CoV-2 may be an effective prevention strategy for the coming winter. 关键词：PREVENTION H1N1 INFLUENZA

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Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and covaccination as an effective method of prevention of COVID-19 and influenza

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