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The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease

查看全文 作  者:Shengdi [1]Chen;Piu [2]Chan;Shenggang [3]Sun;Haibo [4]Chen;Baorong [5]Zhang;Weidong [6]Le;Chunfeng [7]Liu;Guoguang [8]Peng;Beisha [9]Tang;Lijuan [10]Wang;Yan [11]Cheng;Ming [12]Shao;Zhenguo [13]Liu;Zhenfu [14]Wang;Xiaochun [15]Chen;Mingwei [16]Wang;Xinhua [17]Wan;Huifang [18]Shang;Yiming [19]Liu;Pingyi [20]Xu;Jian [21]Wang;Tao [22]Feng;Xianwen [23]Chen;Xingyue [24]Hu;Anmu [25]Xie;Qin [1]Xiao 高影响力作者 机构地区:[1]Department of Neurology,Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;[2]Xuanwu Hospital affiliated to Capital Medical University,Beijing,China;[3]Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan,China;[4]Beijing Hospital,Beijing,China;[5]The Second Hospital affiliated to Zhejiang University School of Medicine,Hangzhou,China;[6]The First Hospital affiliated to Dalian Medical University,Dalian,China;[7]The Second Affiliated Hospital of Soochow University,Suzhou,China;[8]The First Hospital affiliated to Chongqing Medical University,Chongqing,China;[9]Xiangya Hospital,Central South University,Changsha,China;[10]Guangdong General Hospital,Guangzhou,China;[11]General Hospital affiliated to Tianjin Medical University,Tianjin,China;[12]Sichuan Rehabilitation Hospital,Chengdu,China;[13]Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine,Shanghai,China;[14]Chinese PLA General Hospital,Beijing,China;[15]Fujian Medical University Union Hospital,Fuzhou,China;[16]The First Hospital affiliated to Hebei Medical University,Shijiazhuang,China;[17]Peking Union Medical College Hospital,Beijing,China;[18]West China Hospital affiliated to Sichuan University,Chengdu,China;[19]Qilu Hospital affiliated to Shandong University,Jinan,China;[20]The First Hospital affiliated to Guangzhou Medical University,Guangzhou,China;[21]Huashan Hospital affiliated to Fudan University,Shanghai,China;[22]Tiantan Hospital affiliated to Capital Medical University,Beijing,China;[23]The First Hospital affiliated to Anhui Medical University,Hefei,China;[24]Sir Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine,Hangzhou,China;[25]The Affiliated Hospital,Qingdao University School of Medicine,Qingdao,China高影响力机构 出  处:《Translational Neurodegeneration》索引2016年第5卷第1期,共12页高影响力期刊 基  金:This work was supported by the National Key Basic Research Program of China[grant numbers G1999054008,2006cb500706,2011CB504104];the National Natural Science Foundation of China[grant number 81430022];the Shanghai Science and Technology Fund[grant number 10411954500]. 摘  要:Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. 关 键 词:Parkinson’s disease Treatment guideline optimal therapeutic options China
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