大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析

查看全文 作　　者：[1]孟夏刘聪 (校 )[2 ][1,2]陈仁杰索引郑湃 (译 )[2 ][3]阚海东索引Francesco [4]Sera Ana Vicedo -[4]Cabrera Ai Milojevic [4]Maria Guo [4]Yuming Tong [4]Shilu Micheline de Sousa Zanotti Stagliorio [4]Coelh Paulo Hilario Nascimento [4]Saldiva Eric [4]Lavigne Patricia Matus [4]Correa Nicolas Valdes [4]Ortega Samuel Osorio [4]Garcia Jan [4]Kysely Ales [4]Urban Hans [4]Orru Marek [4]Maasikmets Jouni J K [4]Jaakkola Niilo [4]Ryti Veronika [4]Huber Alexandra [4]Schneider Klea [4]Katsouyanni Antonis [4]Analitis Masahiro [4]Hashizume Yasushi [4]Honda Chris Fook Sheng [4]Ng Baltazar [4]Nunes João Paulo [4]Teixeira Iulian Horia [4]Holobaca Simona [4]Fratianni Ho [4]Kim Aurelio [4]Tobias [4]Carmeníniguez Bertil [4]Forsberg [4]ChristoferÅström Martina S [4]Ragettli Yue -Liang Leon [4]Guo Shih -Chun [4]Pan Shanshan [4]Li Michelle L [4]Bell Antonella [4]Zanobetti Joel [4]Schwartz Tangchun [4]Wu Antonio [4]Gasparrini

机构地区：[1]复旦大学公共卫生学院、公共卫生安全教育部重点实验室(复旦大学)、卫生部卫生技术评估重点实验室(复旦大学),中国上海;[2]北京大学公共卫生学院;[3]复旦大学公共卫生学院;[4]不详

出　　处：《英国医学杂志中文版》索引2021年第24卷第8期,共8页

基　　金：HaK was supported by the National Natural Science Foundation of China(92043301,82030103,and 91843302)and China Medical Board Collaborating Program(16-250);AG and FS were supported by the Medical Research Council,UK(MK/M022625/1);the Natural Environment Research Council,UK(NE/R009384/1);and the European Union's Horizon 2020 Project Exhaustion(820655);VH was supported by the Spanish Ministry of Science and Innovation(PCIN-2017-046);and the German Federal Ministry of Education and Research(01 LSI201A2);YH and MH were supported by the Environment Research and Technology Development Fund(JPMEERF15S11412);the Environmental Restoration and Conservation Agency,Japan.JK and AU were supported by the Czech Science Foundation(18-22125S);ST was supported by the Shanghai Municipal Science and Technology Commission(18411951600);Y-LLG was supported by a Career Development Fellowship of the Australian National Health and Medical Research Council(APP1163693);SL was supported by an Early Career Fellowship of the Australian National Health and Medical Research Council(APP1109193);JJKJJ and NR were supported by the Academy of Finland(310372);The funders had no role in considering the study design or in the collection,analysis,interpretation of data,writing of the report,or decision to submit the article for publication. 摘　　要：目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 关键词：总死亡率 meta分析总死亡人数死亡风险广义线性模型二氧化氮高收入国家结局指标

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大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析

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