Impact of mechanical circulatory support and immunomodulation therapy on outcome of patients with fulminant myocarditis: Chinese registry of fulminant myocarditis

查看全文 作　　者：Ning [1]Zhou;Yuhua [2]Zhao;Jiangang [1]Jiang;Lan [3]Shen;Junming [4]Li;Jing [5]Wan;Xueping [6]Ma;Jing [7]Zhang;Enrico [8]Ammirati;Dao Wen [1]Wang

机构地区：[1]Division of Cardiology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Wuhan,China;[2]Division of Cardiology,Dongguan Kanghua Hospital,Dongguan,China;[3]Division of Cardiology,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai,China;[4]Division of Cardiology,The First Hospital of Yichang City,Yichang,China;[5]Division of Cardiology,Zhongnan Hospital of Wuhan University,Wuhan,China;[6]Division of Cardiology,General Hospital of Ningxia Medical University,Yinchuan,China;[7]Division of Cardiology,Henan Provincial People’s Hospital,Zhengzhou,China;[8]'De Gasperis'Cardio Center and Transplant Center,ASST Grande Ospedale Metropolitano Niguarda,Milan,Italy

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第11期,共2页

基　　金：This work grants from the National Natural Science Foundation of China(No.81790624 and 81630010,82070316);National Key R&D Program of China(NO.2017YFC0909400). 摘　　要：Dear Editor,Patients presenting with acute myocarditis and sudden hemodynamic instability (termed fulminant myocarditis [FM]) still have a high mortality and need for heart transplantation, up to 28% at 60 days.1,2,3 Recent scientific statements and expert opinion consensus suggests early use of temporary mechanical circulatory supports (t-MCS).3,4 Specifically, Chinese scientific statement proposed an extensive use of t-MCS combined with immunoregulatory therapy (IT),4 although formal trials are lacking. We present a multicenter, retrospective study to compare the outcome of patients who were treated with t-MCS and IT vs. patients who didn’t receive these treatments. We included patients with the diagnosis of FM based on the presence of viral prodromal signs/symptoms followed by acute onset of severe heart failure (HF) without other relevant differential diagnosis or pre-existing cardiac disorders. Patients who received both t-MCS and IT during hospitalization were classified as t-MCS+IT group. 关键词：PATIENTS MYOCARDITIS DIAGNOSIS

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Impact of mechanical circulatory support and immunomodulation therapy on outcome of patients with fulminant myocarditis: Chinese registry of fulminant myocarditis

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