A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes

查看全文 作　　者：Yingtong [1,2]Cui;Ying [1,2]Huang;Xuejuan [1,2]Zhang;Xiangyun [3]Lu;Jun [4]Xue;Guanlin [2]Wang;Ping [1]Hu;Xiao [2]Yue;Ziyu [2,5]Zhao;Xin [2]Pan;Chuanbin [1,2]Wu

机构地区：[1]School of Pharmaceutical Science,Jinan University,Guangzhou 510006,China;[2]School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;[3]Micromeritics Instrument(Shanghai)Ltd”Shanghai 200135,China;[4]MEGGLE Group Shanghai Representative Office,Shanghai 201315,China;[5]Department of Pharmacology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China

出　　处：《Acta Pharmaceutica Sinica B》索引2022年第12卷第1期,共14页

基　　金：funded by the Fundamental Research Funds for the Central Universities(Nos.21620434 and 2162014,China);the National Natural Science Foundation of China(Nos.81673375 and 81703431);the Science and Technology Foundation Guangzhou(No.201509030006,China);the National Students Innovation Training Program of China(No.201901390,China)。 摘　　要：Dry powder inhalers(DPIs) had been widely used in lung diseases on account of direct pulmonary delivery, good drug stability and satisfactory patient compliance. However, an indistinct understanding of pulmonary delivery processes(PDPs) hindered the development of DPIs. Most current evaluation methods explored the PDPs with over-simplified models, leading to uncompleted investigations of the whole or partial PDPs. In the present research, an innovative modular process analysis platform(MPAP) was applied to investigate the detailed mechanisms of each PDP of DPIs with different carrier particle sizes(CPS). The MPAP was composed of a laser particle size analyzer, an inhaler device,an artificial throat and a pre-separator, to investigate the fluidization and dispersion, transportation,detachment and deposition process of DPIs. The release profiles of drug, drug aggregation and carrier were monitored in real-time. The influence of CPS on PDPs and corresponding mechanisms were explored. The powder properties of the carriers were investigated by the optical profiler and Freeman Technology four powder rheometer. The next generation impactor was employed to explore the aerosolization performance of DPIs. The novel MPAP was successfully applied in exploring the comprehensive mechanism of PDPs, which had enormous potential to be used to investigate and develop DPIs. 关键词：Dry powder inhaler Carrier particle size Pulmonary delivery process Real-time monitor Quick detection

相关文献

参考文献（52）
引证文献（1）
耦合文献（33）

参考文献(52)

引证文献(1)

耦合文献(33)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes

参考文献(52)

引证文献(1)

耦合文献(33)

用户提示