A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy

查看全文 作　　者：Xi [1,2,3]Hu;Nan [1]Wang;Xia [1]Guo;Zeyu [1,4]Liang;Heng [1]Sun;Hongwei [1]Liao;Fan [1]Xia;Yunan [1]Guan;Jiyoung [1,5]Lee;Daishun [1,2,4]Ling;Fangyuan [1,4]Li

机构地区：[1]Institute of Pharmaceutics,Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,People’s Republic of China;[2]Frontiers Science Center for Transformative Molecules,State Key Laboratory of Oncogenes and Related Genes,School of Chemistry and Chemical Engineering,National Center for Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,People’s Republic of China;[3]Department of Clinical Pharmacy,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,People’s Republic of China;[4]WLA Laboratories,Shanghai 201203,People’s Republic of China;[5]Department of Biomedical-Chemical Engineering,The Catholic University of Korea,43 Jibong-ro,Wonmi-gu,Bucheon-Si,Gyeonggi-do 14662,Republic of Korea

出　　处：《Nano-Micro Letters》索引2022年第14卷第6期,共12页

基　　金：We acknowledge financial support by the National Natural Science Foundation of China(32071374,32000985,81761148029,81620108028);Program of Shanghai Academic Research Leader under the Science and Technology Innovation Action Plan(21XD1422100);Leading Talent of“Ten Thousand Plan”-National High-Level Talents Special Support Plan,One Belt and One Road International Cooperation Project from Key Research and Development Program of Zhejiang Province(2019C04024);the Zhejiang Provincial Natural Science Foundation of China(LR22C100001,LGF19C100002,LQ21H300003);Zhejiang Province Medical and Health Science Research Project(2021KY666),and Zhejiang Pharmaceutical Association(2019ZYY12);Open access funding provided by Shanghai Jiao Tong University 摘　　要：The structural change-mediated catalytic activity regulation plays a significant role in the biological functions of natural enzymes.However,there is virtually no artificial nanozyme reported that can achieve natural enzyme-like stringent spatiotemporal structure-based catalytic activity regulation.Here,we report a subnanostructural transformable gold@ceria(STGC-PEG)nanozyme that performs tunable catalytic activities via near-infrared(NIR)light-mediated sub-nanostructural transformation.The gold core in STGC-PEG can generate energetic hot electrons upon NIR irradiation,wherein an internal sub-nanostructural transformation is initiated by the conversion between CeO;and electron-rich state of CeO;-x,and active oxygen vacancies generation via the hot-electron injection.Interestingly,the sub-nanostructural transformation of STGC-PEG enhances peroxidase-like activity and unprecedentedly activates plasmon-promoted oxidase-like activity,allowing highly efficient low-power NIR light(50 m W cm;)-activated photocatalytic therapy of tumors.Our atomic-level design and fabrication provide a platform to precisely regulate the catalytic activities of nanozymes via a light-mediated sub-nanostructural transformation,approaching natural enzyme-like activity control in complex living systems. 关键词：Nanozymes Sub-nanostructural transformation Catalytic activity Reactive oxygen species Photocatalytic therapy

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A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy

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