Signaling pathways and targeted therapy for myocardial infarction

查看全文 作　　者：Qing [1,2]Zhang;Lu [1,2]Wang;Shiqi [1,2]Wang;Hongxin [1,2]Cheng;Lin [1,2]Xu;Gaiqin [1,2]Pei;Yang [1,2]Wang;Chenying [3,4]Fu;Yangfu [5]Jiang;Chengqi [1,2]He;Quan [1,2]Wei

机构地区：[1]Rehabilitation Medicine Center and Institute of Rehabilitation Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan,PR China;[2]Key Laboratory of Rehabilitation Medicine in Sichuan Province,Chengdu,Sichuan,PR China;[3]National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu,Sichuan,PR China;[4]Aging and Geriatric Mechanism Laboratory,West China Hospital,Sichuan University,Chengdu,Sichuan,PR China;[5]State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,Sichuan,PR China

出　　处：《Signal Transduction and Targeted Therapy》索引2022年第7卷第4期,共38页

基　　金：National Natural Science Foundation of China(Grant No.82172534);National Key R&D Program of China(Grant No.2020YFC2008502);1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University. 摘　　要：Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high mortality.Whilst there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are emerging.Evidence of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem cells.These signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,etc.Since signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and promising.Hence,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel therapies.In this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,etc.so as to repair and re-functionalize damaged hearts. 关键词：INFLAMMATION INFARCTION instance

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Signaling pathways and targeted therapy for myocardial infarction

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