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The Gut Microbiome and Ferroptosis in MAFLD

查看全文 作　　者：Jie [1,2]Ji;Liwei [1,2]Wu;Jue [3]Wei;Jianye [1]Wu;Chuanyong [1,2]Guo 高影响力作者 机构地区：[1]Department of Gastroenterology,Putuo People’s Hospital,Tongji University,Shanghai,China;[2]Department of Gastroenterology,Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Shanghai,China;[3]Department of Gastroenterology Shanghai Tongren Hospital,Shanghai Jiaotong University School of Medicine,Shanghai,China高影响力机构 出　　处：《Journal of Clinical and Translational Hepatology》索引2023年第11卷第1期,共14页高影响力期刊 基　　金：the National Natural Science Foundation of China (grant number:82002539);the Natural Science Foundation of Shanghai (grant number:19ZR1447700);the Health System Innovation Project of Shanghai Putuo Science and Technology Commission (grant numbers:PTKWWS201903);The Yangfan Plan of Shanghai Science and Technology Commission (grant no.21YF1435400);Shanghai Municipal Health Commission,China (grant no.201840233). 摘　　要：Metabolic-associated fatty liver disease(MAFLD)is a new disease definition,and is proposed to replace the previous name,nonalcoholic fatty liver disease(NAFLD).Globally,MAFLD/NAFLD is the most common liver disease,with an incidence rate ranging from 6%to 35%in adult populations.The pathogenesis of MAFLD/NAFLD is closely related to insulin resistance(IR),and the genetic susceptibility to acquired metabolic stress-associated liver injury.Similarly,the gut microbiota in MAFLD/NAFLD is being revaluated by scientists,as the gut and liver influence each other via the gut-liver axis.Ferroptosis is a novel form of programmed cell death caused by iron-dependent lipid peroxidation.Emerging evidence suggests that ferroptosis has a key role in the pathological progression of MAFLD/NAFLD,and inhibition of ferroptosis may become a novel therapeutic strategy for the treatment of NAFLD.This review focuses on the main mechanisms behind the promotion of MAFLD/NAFLD occurrence and development by the intestinal microbiota and ferroptosis.It outlines new strategies to target the intestinal microbiota and ferroptosis to facilitate future MAFLD/NAFLD therapies. 关 键 词：Gut microbiota Ferroptosis Nonalcoholic fatty liver disease Gutliver axis
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