Palladium-Catalyzed Long-Range Isomerization of Aryl Olefins

查看全文 作　　者：Qianyi [1]Ge;Jingjie [2]Meng;Huikang [2]Liu;Zehua [1]Yang;Zhengxing [2]Wu;Wanbin [2]Zhang 机构地区：[1]Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research,Institute of Pharmacy&Pharmacology School of Pharmaceutical Science,Hengyang Medical School,University of South China,Hengyang,Hunan,421001 China;[2]Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,Frontiers Science Center for Transformative Molecules,School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,800 Dongchuan Road,Shanghai,200240 China 出　　处：《Chinese Journal of Chemistry》索引2022年第40卷第19期,共7页 基　　金：We would like to thank the Research Foundation of Education Bureau of Hunan Province(No.19K079);the National Key R&D Program of China(No.2018YFE0126800)for financial support.We thank the Instrumental Analysis Center of SJTU for characterza-tion. 摘　　要：Long-range olefin isomerization could lead to the remote functionalization of hydrocarbon chains,which is advantageous with regards to atom-,step-,and redox economy.However,present methodologies for long-range olefin isomerization are mainly focused on heteroatom directed remote olefin migration;studies using aryl groups as the directing group are limited.The limited examples either utilize aryl olefins with special substituted groups on a benzene ring,or use elaborately optimized ligands or co-catalysts to accelerate the isomerization.A more simple catalytic system for general aryl olefins,without the need for special ligands or co-catalysts,was to be developed.Herein,we report a Pd-catalyzed long-range olefin isomerization(up to 15 units)for general aryl olefins via a 1,2-hydrogen shift mechanism.This methodology provides a simple pathway to long-range olefin isomerization without the participation of special ligands or co-catalysts. 关 键 词：Palladium/Long-range ISOMERIZATION Arylolefin/1,2-Hydrogenshift