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CuS-PNIPAm nanoparticles with the ability to initiatively capture bacteria for photothermal treatment of infected skin

查看全文 作　　者：Zizhen [1]Wang;Zishuo [1]Hou;Peiwen [1]Wang;Fan [1]Chen;Xianglin [1,2]Luo 高影响力作者 机构地区：[1]College of Polymer Science and Engineering,Sichuan University,Chengdu,People’s Republic of China;[2]State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu,People’s Republic of China高影响力机构 出　　处：《Regenerative Biomaterials》索引2022年第9卷第1期,共13页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(no.51973130);by the International Cooperation and Exchange in Science and Technology Research Project of Sichuan Province(2021YFH0087). 摘　　要：Copper sulfide nanoparticles(CuS NPs)have shown great potential in various application fields,especially in biomedical engineering fields.CuS NPs,with the ability to actively capture and kill bacteria and without the worry of biocompatibility,will greatly expand their applications.Herein,a four-arm star thermosensitive polyisopropylacrylamide(4sPNIPAm)was used to modify CuS NPs(CuS-PNIPAm NPs).The obtained NPs displayed the controlled release of copper ions and higher photothermal conversion ability in comparison with contrast materials CuS-PEG NPs and CuS NPs.Aggregation of CuS-PNIPAm NPs at above 34℃resulted in capturing bacteria by forming the aggregates of NPs-bacteria.Both Staphylococcus aureus and Escherichia coli co-cultured with CuS-PNIPAm NPs were completely killed upon near-infrared irradiation in minutes.Furthermore,CuS-PNIPAm NPs were verified to be a photothermal agent without toxic effect.In in vivo experiment,the NPs effectively killed the bacteria in the wound and accelerated the process of wound repairment.Overall,photothermal treatment by CuS-PNIPAm NPs demonstrates the ability to actively capture and kill bacteria,and has a potential in the treatment of infected skin and the regeneration of skin tissues.The therapy will exert a far-reaching impact on the regeneration of stubborn chronic wounds. 关 键 词：capturing bacteria wound healing acceleration photothermal ablation ion-controlled release
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