Platelet membrane-coated C-TiO_(2) hollow nanospheres for combined sonodynamic and alkyl-radical cancer therapy

查看全文 作　　者：Weihong [4]Guo;Tao [2]Wang;Chunyu [1,5]Huang;Shipeng [6]Ning;Qinglong [2]Guo;Wei [3]Zhang;Huawei [6]Yang;Daoming [4]Zhu;Qinqin [1]Huang;Haisheng [3]Qian;Xianwen [3]Wang

机构地区：[1]Department of Molecular Pathology,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China;[2]Department of Orthopaedics,The Second Hospital of Anhui Medical University,Hefei 230601,China;[3]School of Biomedical Engineering,Research and Engineering Center of Biomedical Materials,Anhui Medical University,Hefei 230032,China;[4]Department of General Surgery&Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor,Nanfang Hospital,The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,China;[5]Department of Radiation and Medical Oncology,Hubei Key Laboratory of Tumor Biological Behaviors,Hubei Cancer Clinical Study Center,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;[6]Department of Breast Surgery,Guangxi Medical University Cancer Hospital,Nanning 530000,China

出　　处：《Nano Research》索引2023年第16卷第1期,共10页

基　　金：This work was supported by the Research fund of Anhui Institute of Translation Medicine(No.2021zhyx-C49);the Foundation of Anhui Medical University(No.2021xkj030);the Anhui Provincial Natural Science Foundation(No.2208085QC81);the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University(No.2021xkjT028);Grants for Scientific Research of BSKY from Anhui Medical University(No.1406012201). 摘　　要：The therapeutic efficiency of sonodynamic therapy(SDT)mainly depends on the presence of oxygen(O_(2))to generate harmful reactive oxygen species(ROS);thus,the hypoxic tumor microenvironment significantly limits the efficacy of SDT.Therefore,the development of oxygen-independent free radical generators and associated combination therapy tactics can be a promising field to facilitate the anticancer capability of SDT.In this study,a biomimetic drug delivery system(C-TiO_(2)/AIPH@PM)composed of an alkyl-radical generator(2,2′-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride,AIPH)-loaded C-TiO_(2) hollow nanoshells(HNSs)as the inner cores,and a platelet membrane(PM)as the outer shells is successfully prepared for synergistic SDT and oxygen-independent alkyl-radical therapy.The PM encapsulation can significantly prolong the blood circulation time of CTiO_(2)/AIPH@PM compared with C-TiO_(2)/AIPH while enabling C-TiO_(2)/AIPH@PM to achieve tumor targeting.C-TiO_(2)/AIPH@PM can efficiently produce ROS and alkyl radicals,which can achieve a more thorough tumor eradication regardless of the normoxic or hypoxic conditions.Furthermore,the generation of these radicals improves the efficiency of SDT.In addition,nitrogen(N_(2))produced due to the decomposition of AIPH enhances the acoustic cavitation effect and lowers the cavitation threshold,thereby enhancing the penetration of CTiO_(2)/AIPH@PM at the tumor sites.Both in vitro and in vivo experiments demonstrate that CTiO_(2)/AIPH@PM possesses good biosafety,ultrasound imaging performance,and excellent anticancer efficacy.This study provides a new strategy to achieve oxygen-independent free radical production and enhance therapeutic efficacy by combining SDT and free radical therapy. 关键词：C-TiO_(2) sonodynamic therapy alkyl-radical therapy combination therapy biomimetic nanomaterials

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Platelet membrane-coated C-TiO_(2) hollow nanospheres for combined sonodynamic and alkyl-radical cancer therapy

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