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The hippo kinases MST1/2 in cardiovascular and metabolic diseases:A promising therapeutic target option for pharmacotherapy

查看全文 作　　者：Yunfei [1]Yin;Mingyue [1]Tan;Lianhua [1]Han;Lei [1]Zhang;Yue [1]Zhang;Jun [1]Zhang;Wanqian [1]Pan;Jiaxiang [1,2,3]Bai;Tingbo [1]Jiang;Hongxia [1]Li 高影响力作者 机构地区：[1]Department of Cardiology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;[2]Department of Orthopedics,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;[3]Department of Orthopedics,the First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of Chin1,Hefei 230001,China高影响力机构 出　　处：《Acta Pharmaceutica Sinica B》索引2023年第13卷第5期,共20页高影响力期刊 基　　金：grants from the National Natural Science Foundation of China(Nos.81770327 and 81100173);Jiangsu Province Health Care Development Special Fund(M2022038,China)。 摘　　要：Cardiovascular diseases(CVDs)and metabolic disorders are major components of noncommunicable diseases,causing an enormous health and economic burden worldwide.There are common risk factors and developmental mechanisms among them,indicating the far-reaching significance in exploring the corresponding therapeutic targets.MST1/2 kinases are well-established proapoptotic effectors that also bidirectionally regulate autophagic activity.Recent studies have demonstrated that MST1/2 influence the outcome of cardiovascular and metabolic diseases by regulating immune inflammation.In addition,drug development against them is in full swing.In this review,we mainly describe the roles and mechanisms of MST1/2 in apoptosis and autophagy in cardiovascular and metabolic events as well as emphasis on the existing evidence for their involvement in immune inflammation.Moreover,we summarize the latest progress of pharmacotherapy targeting MST1/2 and propose a new mode of drug combination therapy,which may be beneficial to seek more effective strategies to prevent and treat CVDs and metabolic disorders. 关 键 词：MST1/2 kinases Regulation Apoptosis AUTOPHAGY Immune Cardiovascular diseases Metabolic diseases Therapy
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