Osteoblastic microRNAs in skeletal diseases:Biological functions and therapeutic implications

查看全文 作　　者：Lei [1,3]Yu;Wenming [1,3]Li;Peng [1,3]Yang;Wei [1,3]Zhang;Huaqiang [1,3]Tao;Gaoran [1,3]Ge;Huilin [1,3]Yang;Jiaxiang [1,3]Bai;Huaiyu [2]Wang;Dechun [1,3]Geng

机构地区：[1]Department of Orthopaedics,The First Affiliated Hospital of Soochow University,188 Shizi Street,Suzhou,Jiangsu 215006,China;[2]Center for Human Tissues and Organs Degeneration,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;[3]Orthopaedic Institute,Medical College,Soochow University,Suzhou,Jiangsu 215000,China

出　　处：《Engineered Regeneration》索引2022年第3卷第3期,共17页

基　　金：supported by grants from the National Natural Sci-ence Foundation of China(82072425,82072498,82074473,81873991,31922040 and 81873990);the Young Medical Talents of Jiangsu Province(QNRC2016751);the Natural Science Foundation of Jiangsu Province(BK20200198,BE2021650);Special Project of Diagno-sis and Treatment Technology for Key Clinical Diseases in Suzhou(LCZX202003,LCZX201824). 摘　　要：Skeletal diseases normally represents a grievous imbalance between osteoblasts for bone formation and osteoclasts for bone resorption.A lack of osteogenic function can make it difficult to repair pathological bone erosion.Therefore,substantial efforts have been made to remedy these issues,with the aid of bioactive molecules,herbs and materials.Following recent insights,the importance of epigenetic gene regulation is increasingly evident,especially microRNAs.MicroRNAs can silence target genes by inhibiting mRNA translation or degrading mRNA molecules by binding to their 3′-untranslated region.There is accumulating evidence indicating that the miRNAs significantly involved in osteogenic gene expression,signaling pathway intervention and programmed cell death.Besides,numerous new target drugs(microRNA inhibitors or agonists)have been proposed to exploit its value in skeletal physiology and pathology.In this review,we mainly discuss the role of microRNAs in the context of skeletal disease-associated osteoblast differentiation,the applications of microRNA polymorphisms as biomarkers for diagnostic and therapeutic targets,and the challenges to meet this goal.Our summary provides novel horizon for improving the therapeutic effect of microRNAs,which may be beneficial to the further clinical translation of microRNAs in the treatments of skeletal diseases. 关键词：Skeletal diseases OSTEOGENESIS Apoptosis MicroRNA Diagnosis Drug delivery

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Osteoblastic microRNAs in skeletal diseases:Biological functions and therapeutic implications

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