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Fantastic voyage: The journey of NLRP3 inflammasome activation

查看全文 作　　者：Xiangyong [1]Que;Sihao [1]Zheng;Qibin [1]Song;Huadong [2]Pei;Pingfeng [1]Zhang 高影响力作者 机构地区：[1]Cancer Center,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China;[2]Department of Oncology,Georgetown Lombardi Comprehensive Cancer Center,Georgetown University Medical Center,Washington,DC 20057,USA高影响力机构 出　　处：《Genes & Diseases》索引2024年第11卷第2期,共11页高影响力期刊 摘　　要：NLRP3 inflammasome,an intracellular multiprotein complex,can be activated by a range of pathogenic microbes or endogenous hazardous chemicals.Its activation results in the release of cytokines such as IL-1β and IL-18,as well as Gasdermin D which eventually causes pyroptosis.The activation of NLRP3 inflammasome is under strict control and regulation by numerous pathways and mechanisms.Its excessive activation can lead to a persistent inflammatory response,which is linked to the onset and progression of severe illnesses.Recent studies have revealed that the subcellular localization of NLRP3 changes significantly during the activation process.In this review,we review the current understanding of the molecular mechanism of NLRP3 inflammasome activation,focusing on the subcellular localization of NLRP3 and the associated regulatory mechanisms.We aim to provide a comprehensive understanding of the dynamic transportation,activation,and degradation processes of NLRP3. 关 键 词：Inflammasome activation Innate immunity NLRP3 NLRP3 inflammasome Subcellular localization
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